Protein Alignment betaTub65B and TUBA1A

DIOPT Version :10

• Sequence 1: NP_729172.1
• Gene: betaTub65B / 117406
• FlyBaseID: FBgn0052396
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_006000.2
• Gene: TUBA1A / 7846
• HGNCID: 20766
• Length: 451
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 161/467 - (34%)
• Similarity: 247/467 - (52%)
• Gaps: 35/467 - (7%)

  Fly     1 MREIVTLQIGGAGNAIGDSFWHVISHEHGV--------DYASGRFGGTSPLQLERINVFFNATAS 57
            |||.:::.:|.||..||::.|.:...|||:        |...|  ||.     :..|.||:.|.:
Human     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIG--GGD-----DSFNTFFSETGA 58

  Fly    58 KRFYARTILIDTEASTIQRLNASS--QLYRPENFVAGSESAGNNFARGYHTDGAAILDQVLENTR 120
            .:...|.:.:|.|.:.|..:...:  ||:.||..:.|.|.|.||:|||::|.|..|:|.||:..|
Human    59 GKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIR 123

  Fly   121 REVESVDSLQGFQLLHSIGGGTGSGLTSLIMEALVEQYPDNLLCNYVTIPSPNMSQVVVEPYNAL 185
            :..:....||||.:.||.|||||||.|||:||.|...|.......:...|:|.:|..||||||::
Human   124 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSI 188

  Fly   186 LSTPALVNNSHLTFCLDNEALFQICNRNLKLKMSGYEHINHIVALTMSGITTCLRFPGQLNAGLR 250
            |:|...:.:|...|.:||||::.||.|||.::...|.::|.::...:|.||..|||.|.||..|.
Human   189 LTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLT 253

  Fly   251 KIYVNMVPFPRLHFLIPGFAPLVTCKQQQFSKGTVSELVQQIFYSNNLLCAIDLRKGKLLTAAGI 315
            :...|:||:||:||.:..:||:::.::....:.:|:|:....|...|.:...|.|.||.:....:
Human   254 EFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLL 318

  Fly   316 FRGRMSPREVDQLMTGVRNKNINNFVDWIPNNIKTAICDIPP--------RGLKMSATFIGNTTA 372
            :||.:.|::|:..:..::.|....||||.|...|..|...||        ..::.:...:.||||
Human   319 YRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTA 383

  Fly   373 IQTLFQRLLDASMSMLRRKAHLHWYTGEGMEEQEFQDAQQELQAIIDDYRSSAEGEDSGGGGGGG 437
            |...:.||......|..::|.:|||.||||||.||.:|::::.|:..||..  .|.||..|.|
Human   384 IAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEE--VGVDSVEGEG-- 444

  Fly   438 GGRSGSAESGEE 449
                  .|.|||
Human   445 ------EEEGEE 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub65B	NP_729172.1	beta_tubulin	2..425	CDD:276956	151/440 (34%)
TUBA1A	NP_006000.2	PTZ00335	1..440	CDD:185562	154/447 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..451		10/29 (34%)