Protein Alignment betaTub65B and TUBA3C

DIOPT Version :10

• Sequence 1: NP_729172.1
• Gene: betaTub65B / 117406
• FlyBaseID: FBgn0052396
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_005992.1
• Gene: TUBA3C / 7278
• HGNCID: 12408
• Length: 450
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 159/471 - (33%)
• Similarity: 245/471 - (52%)
• Gaps: 44/471 - (9%)

  Fly     1 MREIVTLQIGGAGNAIGDSFWHVISHEHGV--------DYASGRFGGTSPLQLERINVFFNATAS 57
            |||.:::.:|.||..||::.|.:...|||:        |...|  ||.     :..|.||:.|.:
Human     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIG--GGD-----DSFNTFFSETGA 58

  Fly    58 KRFYARTILIDTEASTIQRLNASS--QLYRPENFVAGSESAGNNFARGYHTDGAAILDQVLENTR 120
            .:...|.:.:|.|.:.:..:...:  ||:.||..:.|.|.|.||:|||::|.|..|:|.||:..|
Human    59 GKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIR 123

  Fly   121 REVESVDSLQGFQLLHSIGGGTGSGLTSLIMEALVEQYPDNLLCNYVTIPSPNMSQVVVEPYNAL 185
            :..:....||||.:.||.|||||||..||:||.|...|.......:...|:|.:|..||||||::
Human   124 KLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSI 188

  Fly   186 LSTPALVNNSHLTFCLDNEALFQICNRNLKLKMSGYEHINHIVALTMSGITTCLRFPGQLNAGLR 250
            |:|...:.:|...|.:||||::.||.|||.::...|.::|.::...:|.||..|||.|.||..|.
Human   189 LTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLT 253

  Fly   251 KIYVNMVPFPRLHFLIPGFAPLVTCKQQQFSKGTVSELVQQIFYSNNLLCAIDLRKGKLLTAAGI 315
            :...|:||:||:||.:..:||:::.::....:.:|:|:....|...|.:...|.|.||.:....:
Human   254 EFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCML 318

  Fly   316 FRGRMSPREVDQLMTGVRNKNINNFVDWIPNNIKTAICDIPP--------RGLKMSATFIGNTTA 372
            :||.:.|::|:..:..::.|....||||.|...|..|...||        ..::.:...:.||||
Human   319 YRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTA 383

  Fly   373 IQTLFQRLLDASMSMLRRKAHLHWYTGEGMEEQEFQDAQQELQAIIDDYR----SSAEGEDSGGG 433
            |...:.||......|..::|.:|||.||||||.||.:|:::|.|:..||.    .|.|.|
Human   384 IAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAE----- 443

  Fly   434 GGGGGGRSGSAESGEE 449
                      ||.|||
Human   444 ----------AEEGEE 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub65B	NP_729172.1	beta_tubulin	2..425	CDD:276956	150/444 (34%)
TUBA3C	NP_005992.1	PTZ00335	1..440	CDD:185562	151/445 (34%)
		MREC motif. /evidence=ECO:0000250|UniProtKB:P68363	1..4		2/2 (100%)