Protein Alignment betaTub65B and TUBB4B

DIOPT Version :10

• Sequence 1: NP_729172.1
• Gene: betaTub65B / 117406
• FlyBaseID: FBgn0052396
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_006079.1
• Gene: TUBB4B / 10383
• HGNCID: 20771
• Length: 445
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 243/458 - (53%)
• Similarity: 318/458 - (69%)
• Gaps: 19/458 - (4%)

  Fly     1 MREIVTLQIGGAGNAIGDSFWHVISHEHGVDYASGRFGGTSPLQLERINVFFNATASKRFYARTI 65
            |||||.||.|..||.||..||.|||.|||:| .:|.:.|.|.||||||||::|.....::..|.:
Human     1 MREIVHLQAGQCGNQIGAKFWEVISDEHGID-PTGTYHGDSDLQLERINVYYNEATGGKYVPRAV 64

  Fly    66 LIDTEASTIQRLNAS--SQLYRPENFVAGSESAGNNFARGYHTDGAAILDQVLENTRREVESVDS 128
            |:|.|..|:..:.:.  .|::||:|||.|...||||:|:|::|:||.::|.||:..|:|.||.|.
Human    65 LVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDC 129

  Fly   129 LQGFQLLHSIGGGTGSGLTSLIMEALVEQYPDNLLCNYVTIPSPNMSQVVVEPYNALLSTPALVN 193
            ||||||.||:|||||||:.:|::..:.|:|||.::..:..:|||.:|..|||||||.||...||.
Human   130 LQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVE 194

  Fly   194 NSHLTFCLDNEALFQICNRNLKLKMSGYEHINHIVALTMSGITTCLRFPGQLNAGLRKIYVNMVP 258
            |:..|:|:|||||:.||.|.|||....|..:||:|:.||||:||||||||||||.|||:.|||||
Human   195 NTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVP 259

  Fly   259 FPRLHFLIPGFAPLVTCKQQQFSKGTVSELVQQIFYSNNLLCAIDLRKGKLLTAAGIFRGRMSPR 323
            ||||||.:||||||.:...||:...||.||.||:|.:.|::.|.|.|.|:.||.|.:||||||.:
Human   260 FPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMK 324

  Fly   324 EVDQLMTGVRNKNINNFVDWIPNNIKTAICDIPPRGLKMSATFIGNTTAIQTLFQRLLDASMSML 388
            |||:.|..|:|||.:.||:|||||:|||:|||||||||||||||||:||||.||:|:.:...:|.
Human   325 EVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMF 389

  Fly   389 RRKAHLHWYTGEGMEEQEFQDAQQELQAIIDDYR--SSAEGEDSGGGGGGGGGRSGSAESGEEEA 451
            ||||.|||||||||:|.||.:|:..:..::.:|:  ..|..|:.|              ..||||
Human   390 RRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEG--------------EFEEEA 440

  Fly   452 TPE 454
            ..|
Human   441 EEE 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub65B	NP_729172.1	beta_tubulin	2..425	CDD:276956	234/426 (55%)
TUBB4B	NP_006079.1	PLN00220	1..427	CDD:215107	235/426 (55%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..445		8/32 (25%)