Protein Alignment betaTub65B and TUBB3

DIOPT Version :10

• Sequence 1: NP_729172.1
• Gene: betaTub65B / 117406
• FlyBaseID: FBgn0052396
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_006077.2
• Gene: TUBB3 / 10381
• HGNCID: 20772
• Length: 450
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 238/455 - (52%)
• Similarity: 316/455 - (69%)
• Gaps: 15/455 - (3%)

  Fly     1 MREIVTLQIGGAGNAIGDSFWHVISHEHGVDYASGRFGGTSPLQLERINVFFNATASKRFYARTI 65
            |||||.:|.|..||.||..||.|||.|||:| .||.:.|.|.||||||:|::|..:|.::..|.|
Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGID-PSGNYVGDSDLQLERISVYYNEASSHKYVPRAI 64

  Fly    66 LIDTEASTIQ--RLNASSQLYRPENFVAGSESAGNNFARGYHTDGAAILDQVLENTRREVESVDS 128
            |:|.|..|:.  |..|...|:||:||:.|...||||:|:|::|:||.::|.||:..|:|.|:.|.
Human    65 LVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDC 129

  Fly   129 LQGFQLLHSIGGGTGSGLTSLIMEALVEQYPDNLLCNYVTIPSPNMSQVVVEPYNALLSTPALVN 193
            ||||||.||:|||||||:.:|::..:.|:|||.::..:..:|||.:|..|||||||.||...||.
Human   130 LQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVE 194

  Fly   194 NSHLTFCLDNEALFQICNRNLKLKMSGYEHINHIVALTMSGITTCLRFPGQLNAGLRKIYVNMVP 258
            |:..|:|:|||||:.||.|.|||....|..:||:|:.||||:||.|||||||||.|||:.|||||
Human   195 NTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVP 259

  Fly   259 FPRLHFLIPGFAPLVTCKQQQFSKGTVSELVQQIFYSNNLLCAIDLRKGKLLTAAGIFRGRMSPR 323
            ||||||.:||||||.....||:...||.||.||:|.:.|::.|.|.|.|:.||.|.:||||||.:
Human   260 FPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMK 324

  Fly   324 EVDQLMTGVRNKNINNFVDWIPNNIKTAICDIPPRGLKMSATFIGNTTAIQTLFQRLLDASMSML 388
            |||:.|..:::||.:.||:|||||:|.|:|||||||||||:|||||:||||.||:|:.:...:|.
Human   325 EVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMF 389

  Fly   389 RRKAHLHWYTGEGMEEQEFQDAQQELQAIIDDYR--SSAEGEDSGGGGGGGGGRSGSAESGEEEA 451
            ||||.|||||||||:|.||.:|:..:..::.:|:  ..|..|:.|          ...|..|||:
Human   390 RRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEG----------EMYEDDEEES 444

  Fly   452  451
            Human   445  444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub65B	NP_729172.1	beta_tubulin	2..425	CDD:276956	230/426 (54%)
TUBB3	NP_006077.2	PLN00220	1..447	CDD:215107	238/455 (52%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..450		7/30 (23%)