DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Desat1 and Scd2

DIOPT Version :9

Sequence 1:	NP_652731.1	Gene:	Desat1 / 117369	FlyBaseID:	FBgn0086687	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_114029.1	Gene:	Scd2 / 83792	RGDID:	621177	Length:	358	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	170/288 - (59%)
Similarity:	217/288 - (75%)	Gaps:	2/288 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLKLVWRNIIAFGYLHLAALYGAYLMVTSAKWQTCILAYFLYVISGLGITAGAHRLWAHRSYKAK 131
            :|:.||||||....||:.||||..| |.|.|..||:.||..||||.|||||||||||:||:|||:
  Rat    67 KLEYVWRNIILMALLHIGALYGITL-VPSCKVYTCLFAYLYYVISALGITAGAHRLWSHRTYKAR 130

  Fly   132 WPLRVILVIFNTIAFQDAAYHWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLCKKHPEVKAK 196
            .|||:.|:|.||:|||:..|.||||||.|||:|||.|||||:.||||||||||||.:|||.||.|
  Rat   131 LPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEK 195

  Fly   197 GKGVDLSDLRADPILMFQKKYYMILMPIACFIIPTVVPMYAWGESFMNAWFVATMFRWCFILNVT 261
            |..:|:|||:|:.::|||::||...:.:.|||:||:||.|.|||:|:|:..|:|..|:..:||.|
  Rat   196 GGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLCVSTFLRYAVVLNAT 260

  Fly   262 WLVNSAAHKFGGRPYDKFINPSENISVAILAFGEGWHNYHHVFPWDYKTAEFGKYSLNFTTAFID 326
            ||||||||.:|.|||||.|:..|||.|::.|.|||:|||||.||:||..:|: ::.:||||.|||
  Rat   261 WLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEY-RWHINFTTFFID 324

  Fly   327 FFAKIGWAYDLKTVSTDIIKKRVKRTGD 354
            ..|.:|.|||.|.||...:..|:||||:
  Rat   325 CMALLGLAYDRKRVSKAAVLARIKRTGE 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Desat1	NP_652731.1	Delta9-FADS-like	97..338	CDD:239582	146/240 (61%)
Desat1	NP_652731.1	FA_desaturase	98..305	CDD:278890	128/206 (62%)
Scd2	NP_114029.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..43
		Delta9-FADS-like	99..336	CDD:239582	145/237 (61%)
		FA_desaturase	101..305	CDD:278890	127/203 (63%)
		Histidine box-1. /evidence=ECO:0000305	119..124		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	156..160		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	297..301		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1461
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2092
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8949
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	LDO	PTHR11351
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880