DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Desat1 and SCD5

DIOPT Version :9

Sequence 1:	NP_652731.1	Gene:	Desat1 / 117369	FlyBaseID:	FBgn0086687	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001032671.2	Gene:	SCD5 / 79966	HGNCID:	21088	Length:	330	Species:	Homo sapiens

Alignment Length:	344	Identity:	167/344 - (48%)
Similarity:	232/344 - (67%)	Gaps:	29/344 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AADAGQSPTKLQEDSTGVLFECD--------VETTDGGLVKDITVMKKAEKRRLKLVWRNIIAFG 79
            |.|||:.|.            ||        :|:::||...:   ...|..:|..:||||::...
Human     5 ATDAGKIPF------------CDAKEEIRAGLESSEGGGGPE---RPGARGQRQNIVWRNVVLMS 54

  Fly    80 YLHLAALYGAYLMVTSAKWQTCILAYFLYVISGLGITAGAHRLWAHRSYKAKWPLRVILVIFNTI 144
            .|||.|:| :.:::..||..|.:.|||.::::.||:||||||||:||||:||.|||:.|.:.|::
Human    55 LLHLGAVY-SLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSM 118

  Fly   145 AFQDAAYHWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLCKKHPEVKAKGKGVDLSDLRADP 209
            |||:..:.|:||||.||||||||||||||.|||||||:|||..:||.:|..||:.:|::||.|||
Human   119 AFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADP 183

  Fly   210 ILMFQKKYYMILMPIACFIIPTVVPMYAWGESFMNAWFVATMFRWCFILNVTWLVNSAAHKFGGR 274
            ::..|:|||.|.:.:.||::||:||.|.||||..|::|:|::.|:...||::||||||||.:|.|
Human   184 VVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNR 248

  Fly   275 PYDKFINPSENISVAILAFGEGWHNYHHVFPWDYKTAEFGKYSLNF--TTAFIDFFAKIGWAYDL 337
            ||||.|:|.:|..||:.|.|||:|||||.||:||..:|||   |||  ||.||||...:|.|.|.
Human   249 PYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFG---LNFNPTTWFIDFMCWLGLATDR 310

  Fly   338 KTVSTDIIKKRVKRTGDGT 356
            |..:..:|:.|..||||.:
Human   311 KRATKPMIEARKARTGDSS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Desat1	NP_652731.1	Delta9-FADS-like	97..338	CDD:239582	138/242 (57%)
Desat1	NP_652731.1	FA_desaturase	98..305	CDD:278890	118/206 (57%)
SCD5	NP_001032671.2	Delta9-FADS-like	71..311	CDD:239582	138/242 (57%)
		FA_desaturase	77..279	CDD:278890	117/201 (58%)
		Histidine box-1. /evidence=ECO:0000305	94..99		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	131..135		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	272..276		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154898
Domainoid	1	1.000	294	1.000	Domainoid score	I1492
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134602
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8474
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800