DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Desat1 and Scd4

DIOPT Version :9

Sequence 1:	NP_652731.1	Gene:	Desat1 / 117369	FlyBaseID:	FBgn0086687	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_899039.2	Gene:	Scd4 / 329065	MGIID:	2670997	Length:	353	Species:	Mus musculus

Alignment Length:	291	Identity:	163/291 - (56%)
Similarity:	216/291 - (74%)	Gaps:	2/291 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLKLVWRNIIAFGYLHLAALYGAYLMVTSAKWQTCILAYFLYVISGLGITAGAHRLWAHRSYKAK 131
            :|:.||||||....||:.||||..| |.|.|..|.:|..|..|::||||||||||||:||:|||:
Mouse    62 KLEYVWRNIIFMALLHVGALYGITL-VPSCKVYTWLLGVFYNVVAGLGITAGAHRLWSHRTYKAR 125

  Fly   132 WPLRVILVIFNTIAFQDAAYHWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLCKKHPEVKAK 196
            .|||:.|::.||:|||:..|.||||||.|||:|||.|||||:.||||||||||||.:|||.||.|
Mouse   126 LPLRIFLIMANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEK 190

  Fly   197 GKGVDLSDLRADPILMFQKKYYMILMPIACFIIPTVVPMYAWGESFMNAWFVATMFRWCFILNVT 261
            ||.:|:|||:|:.::|||::||.:.:.:...|:||:||.|.|||:|.::..|:...|:..:||.|
Mouse   191 GKNLDMSDLKAEKLVMFQRRYYKLAVTLMFIILPTLVPWYLWGETFQHSLCVSNFLRYAVLLNFT 255

  Fly   262 WLVNSAAHKFGGRPYDKFINPSENISVAILAFGEGWHNYHHVFPWDYKTAEFGKYSLNFTTAFID 326
            ||||||||.:|.||||:.|...||..|::.:.|||:|||||.||:||..:|: ::.:||||.|||
Mouse   256 WLVNSAAHLYGYRPYDRGIGARENPFVSMASLGEGFHNYHHTFPYDYSVSEY-RWHINFTTFFID 319

  Fly   327 FFAKIGWAYDLKTVSTDIIKKRVKRTGDGTH 357
            ..|.:|.|||.|.||..::..|:||||||:|
Mouse   320 CMAALGLAYDRKKVSKAVVLARIKRTGDGSH 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Desat1	NP_652731.1	Delta9-FADS-like	97..338	CDD:239582	136/240 (57%)
Desat1	NP_652731.1	FA_desaturase	98..305	CDD:278890	118/206 (57%)
Scd4	NP_899039.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Delta9-FADS-like	94..331	CDD:239582	135/237 (57%)
		FA_desaturase	94..300	CDD:278890	119/205 (58%)
		Histidine box-1. /evidence=ECO:0000305	114..119		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	151..155		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	292..296		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1524
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2119
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8712
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840