Protein Alignment prt and SLC18A3

DIOPT Version :9

• Sequence 1: NP_001097887.1
• Gene: prt / 117368
• FlyBaseID: FBgn0043005
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_003046.2
• Gene: SLC18A3 / 6572
• HGNCID: 10936
• Length: 532
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 162/595 - (27%)
• Similarity: 259/595 - (43%)
• Gaps: 135/595 - (22%)

  Fly    21 QAAVQLNAPGRRSSTPSGA---NGSSNRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTS 82
            :.|.|..|...:.|...||   .....|.|:.|||.:||||||||..|||||:|||:|.:.
Human     5 EPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMR---- 65

  Fly    83 SAVVLSLEDTSSFSKLGYRSGESPGGGH-----PQLYISKHPIPGKSMVNFTLLQLSTEATTTTT 142
                                    |||.     |:::....|:|..:         :..|.|..|
Human    66 ------------------------GGGEGPTRTPEVWEPTLPLPTPA---------NASAYTANT 97

  Fly   143 SIATTTNSPHNSTSMQSPPKLTVGQSGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTL 207
            |.:.|...|..|...                                 |.:...|
Human    98 SASPTAAWPAGSALR---------------------------------PRYPTES---------- 119

  Fly   208 TQENGSIGLLLAMKALVQLIFNPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVAR 272
              |:..||:|.|.||::||:.||:.|....:..|.:|:::|...:..|:::|...|.|..|..||
Human   120 --EDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAAR 182

  Fly   273 AVQGVGSACINICGMSLVAQHYPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFII 337
            ::||:|||..:..|::::|..||||..||:.:|:.|..|:.|.|:..|||||||:..||..||::
Human   183 SLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLV 247

  Fly   338 LSTLMFLSLGLQLLTMDLTVQPEVVVEDR-------PKWRSLLECKMILAIVLAIWFSTSTMAML 395
            |:.   :||...||.:.:..........|       |..|.:|: ..|..:..|:......:|.|
Human   248 LAA---VSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLD-PYIAVVAGALTTCNIPLAFL 308

  Fly   396 EPCLPIWLIQYLKPNKWQLGTVFIPDSVGYFVGTNFFGSIAYKYGQVK--VSCISLLLVGVASIL 458
            ||.:..|:...:..::|::|..::|..|.:.:|......:|.:|..::  ...:.|.::|.:|.:
Human   309 EPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCI 373

  Fly   459 IPSATTVAQLLLPHFALGLGIGVIDAALVPLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTS 523
            :|:..:.|.|::....|..||.::|.||:|.||..||.           ..:|.||:||||...|
Human   374 VPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDV-----------RHVSVYGSVYAIADIS 427

  Fly   524 VSLAYCLAPLIGGELAQTFGFAWLMRIVGIFNMIYGPILVYLHQ--------------------- 567
            .|:||.|.|::.|.:..:.||..|...:|:.|::|.|:|:.|..
Human   428 YSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQG 492

  Fly   568 KYDPKALREQ 577
            .||...|||:
Human   493 LYDAVRLRER 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	112/361 (31%)
		MFS_1	212..532	CDD:284993	102/328 (31%)
SLC18A3	NP_003046.2	MFS	124..458	CDD:119392	108/348 (31%)
		MFS_1	124..436	CDD:284993	102/326 (31%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250|UniProtKB:O35304	471..532		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..523		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820