DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prt and SLC18A2

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_003045.2	Gene:	SLC18A2 / 6571	HGNCID:	10935	Length:	514	Species:	Homo sapiens

Alignment Length:	550	Identity:	182/550 - (33%)
Similarity:	293/550 - (53%)	Gaps:	94/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVV--------LSLEDT--SSFSKL 98
            :|.||..||:||||||||||||:|||:|.||.|::.:.::..:        .|:.|:  |.||
Human    18 SRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFS-- 80

  Fly    99 GYRSGESPGGGHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSPHNSTSMQSPPKL 163
                          .|.:...:.|.:..:.||.|.:|:               |..|:..:.|
Human    81 --------------YYDNSTMVTGNATRDLTLHQTATQ---------------HMVTNASAVP-- 114

  Fly   164 TVGQSGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQENGSIGLLLAMKALVQLIF 228
                                              :|..:::..|..||..:|||.|.||.||||.
Human   115 ----------------------------------SDCPSEDKDLLNENVQVGLLFASKATVQLIT 145

  Fly   229 NPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSACINICGMSLVAQH 293
            ||.:|..:::.||.:||..|...:.:|:::|....||..||:||::||:||:|.::.||.::|..
Human   146 NPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASV 210

  Fly   294 YPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSLGLQLLTMDLT-V 357
            |.::..|..||||.||.:|:|||:|.|||.:||:.:||:|||::|:.|:.|...:||..:..: |
Human   211 YTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRV 275

  Fly   358 QPEVVVEDRPKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQYLKPNKWQLGTVFIPDS 422
            |||  .:......:||:...||....:|.|:...:|||||.||||:::.:...|||||..|:|.|
Human   276 QPE--SQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPAS 338

  Fly   423 VGYFVGTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLPHFALGLGIGVIDAALV 487
            :.|.:|||.||.:|:|.|:...:.:.:::|||:.:.||.|..:..|:.|:|.:|..||::|::::
Human   339 ISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMM 403

  Fly   488 PLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGGELAQTFGFAWLMRIVG 552
            |::...||.           ..:|.||:||||...:..:.|.:.|..||.:|:..||.|||.|:|
Human   404 PIMGYLVDL-----------RHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIG 457

  Fly   553 IFNMIYGPILVYLHQ---KYDPKALREQHN 579
            |.::::.|:..:|..   |.:..|:...||
Human   458 IIDILFAPLCFFLRSPPAKEEKMAILMDHN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	135/353 (38%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	122/320 (38%)
SLC18A2	NP_003045.2	MFS_1	130..437	CDD:311564	122/319 (38%)
SLC18A2	NP_003045.2	2_A_01_02	132..273	CDD:273318	62/140 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S3897
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.980