DRSC/TRiP Functional Genomics Resources

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Protein Alignment prt and SLC18A1

DIOPT Version :9

Sequence 1:NP_001097887.1 Gene:prt / 117368 FlyBaseID:FBgn0043005 Length:602 Species:Drosophila melanogaster
Sequence 2:NP_001129163.1 Gene:SLC18A1 / 6570 HGNCID:10934 Length:525 Species:Homo sapiens


Alignment Length:561 Identity:187/561 - (33%)
Similarity:292/561 - (52%) Gaps:88/561 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 LNAPGRRSSTPSGANGSSNRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVVLSLE 90
            |:||.|...     .|.::|.|:.|:|::||||||||.||:|||:|.:|..:|          .:
Human     6 LDAPQRLLK-----EGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDME----------FK 55

  Fly    91 DTSSFSKLGYRSGESPGGGHPQLYISKHPI--PGKSMVNFTLLQLSTEAT--TTTTSIATTTNSP 151
            :.:|...||: :|.||           |.:  |..|.: |:....:|.|.  :..:.||..    
Human    56 EVNSSLHLGH-AGSSP-----------HALASPAFSTI-FSFFNNNTVAVEESVPSGIAWM---- 103

  Fly   152 HNSTSMQSPPKLTVGQSGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELT--LTQENGSI 214
             |.|:...||                            |.|...|::.|:..:.|  |.:|...:
Human   104 -NDTASTIPP----------------------------PATEAISAHKNNCLQGTGFLEEEITRV 139

  Fly   215 GLLLAMKALVQLIFNPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGS 279
            |:|.|.||::||:.||.||..:::.||.:|:..|...:.||:::|....:|..|.|||.:||:||
Human   140 GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGS 204

  Fly   280 ACINICGMSLVAQHYPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFL 344
            :..::.|:.::|..|.::..|.:.||..||.:|||:|:|.|||.::|:.:||||||:||:.|..|
Human   205 SFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALL 269

  Fly   345 SLGLQLLTMDLTVQPEVVVEDRPKWR---SLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQY 406
            ...|||..:    ||..|..:..|..   .||:...||....:|.|:...:|:|||.||||::|.
Human   270 DGALQLCIL----QPSKVSPESAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQT 330

  Fly   407 LKPNKWQLGTVFIPDSVGYFVGTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLP 471
            :...|||||..|:|.||.|.:|||.||.:|.|.|:...|.|.:|:||.:.:.:|.|..:..|:.|
Human   331 MCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGP 395

  Fly   472 HFALGLGIGVIDAALVPLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGG 536
            :..|||.||::|::::|::...||.           ...|.||:||||...:..:.:.:.|..||
Human   396 NAGLGLAIGMVDSSMMPIMGHLVDL-----------RHTSVYGSVYAIADVAFCMGFAIGPSTGG 449

  Fly   537 ELAQTFGFAWLMRIVGIFNMIYGPILVYLHQKYDPKALREQ 577
            .:.:..||.|||.|.|:.|::|.|:..||.   .|.|..|:
Human   450 AIVKAIGFPWLMVITGVINIVYAPLCYYLR---SPPAKEEK 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
prtNP_001097887.1 MFS 212..565 CDD:119392 132/355 (37%)
MFS_1 212..532 CDD:284993 119/322 (37%)
SLC18A1NP_001129163.1 MFS_1 139..445 CDD:284993 119/320 (37%)
2_A_01_02 140..281 CDD:273318 58/144 (40%)
MFS 302..>479 CDD:119392 70/187 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..525
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3764
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59108
OrthoDB 1 1.010 - - D406900at33208
OrthoFinder 1 1.000 - - FOG0000700
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23506
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.930

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