Protein Alignment prt and Slc18a3

DIOPT Version :9

• Sequence 1: NP_001097887.1
• Gene: prt / 117368
• FlyBaseID: FBgn0043005
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_113851.1
• Gene: Slc18a3 / 60422
• RGDID: 62072
• Length: 530
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 158/587 - (26%)
• Similarity: 263/587 - (44%)
• Gaps: 110/587 - (18%)

  Fly    25 QLNAPGRRSSTPSGA---NGSSNRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVV 86
            |..|...:.|...||   .....|.|:.|||.:||||||||..|||||:|||:|.:...:....:
  Rat     9 QARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSEGPTL 73

  Fly    87 LSLEDTSSFSKLGYRSGESPGGGHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSP 151
            :|                         .:.:..:|..::.|.:....:|.|:.|....|.:...|
  Rat    74 VS-------------------------EVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRP 113

  Fly   152 HNSTSMQSPPKLTVGQSGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQENGSIGL 216
            ...|.                                                    .|:..||:
  Rat   114 RYPTE----------------------------------------------------SEDVKIGV 126

  Fly   217 LLAMKALVQLIFNPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSAC 281
            |.|.||::||:.||:.|....:..|.:|:::|...:..|:::|...|.|..|..||::||:|||.
  Rat   127 LFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAF 191

  Fly   282 INICGMSLVAQHYPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSL 346
            .:..|::::|..||||..||:.:|:.|..|:.|.|:..|||||||:..||..||::|:.   :||
  Rat   192 ADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAA---VSL 253

  Fly   347 GLQLLTMDLTVQPEVVVEDR-------PKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLI 404
            ...||.:.:..........|       |..|.:|: ..|..:..|:......:|.|||.:..|:.
  Rat   254 FDALLLLAVAKPFSAAARARANLPVGTPIHRLMLD-PYIAVVAGALTTCNIPLAFLEPTIATWMK 317

  Fly   405 QYLKPNKWQLGTVFIPDSVGYFVGTNFFGSIAYKYGQVK--VSCISLLLVGVASILIPSATTVAQ 467
            ..:..::|::|.|::|..|.:.:|......:|.:|..::  ...:.|.::||:|.::|:..:.|.
  Rat   318 HTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAP 382

  Fly   468 LLLPHFALGLGIGVIDAALVPLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAP 532
            |::....|..||.::|.||:|.||..||.           ..:|.||:||||...|.|:||.|.|
  Rat   383 LVVSLCGLCFGIALVDTALLPTLAFLVDV-----------RHVSVYGSVYAIADISYSVAYALGP 436

  Fly   533 LIGGELAQTFGFAWLMRIVGIFNMIYGPILVYLHQKYDPKALREQHNDMLLQSSGRGSRYKQLYN 597
            ::.|.:..:.||..|...:|:.|::|.|:|:.| :............|:||....:|     ||:
  Rat   437 IVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLL-RNVGLLTRSRSERDVLLDEPPQG-----LYD 495

  Fly   598 SM 599
            ::
  Rat   496 AV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	114/361 (32%)
		MFS_1	212..532	CDD:284993	104/328 (32%)
Slc18a3	NP_113851.1	MFS_SLC18A3_VAChT	36..459	CDD:340941	140/514 (27%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250|UniProtKB:O35304	471..530		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..530

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930