DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prt and slc18a1

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_012814578.1	Gene:	slc18a1 / 594935	XenbaseID:	XB-GENE-5738585	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	147/532 - (27%)
Similarity:	250/532 - (46%)	Gaps:	100/532 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVVLSLEDTSSFSKLGYRSGESPGG 108
            :|..|.::|.:.:.:|.:|.|:|.||.|..|..:|...                 |.|:.::..|
Frog    17 SRAPILLVVAVVMFVDCILFTIIAPIAPALLYHIEYGR-----------------GNRTFKNSSG 64

  Fly   109 GHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSPHNSTSMQSPPKLTVGQSGGTNV 173
            .:|   :|.:                                                    .::
Frog    65 QYP---VSNY----------------------------------------------------DSI 74

  Fly   174 TGIGHKSRNRKLASGHPPTHD------NSSNDNSN----KELTLTQENGSIGLLLAMKALVQLIF 228
            ..:.|...:||     .|.||      .|..|..|    |:. |.:||..:|||||:||.:||:|
Frog    75 FNLSHLEDSRK-----GPYHDQIINITESPGDKKNCYEGKDF-LNEENVRVGLLLAIKAFLQLLF 133

  Fly   229 NPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSACINICGMSLVAQH 293
            |||||...::.||..|:..|...:::|:|:|....||..|.|||..||:||:...:..:..:||.
Frog   134 NPIVGKLVTRIGYDAPMFFGFVIVVVSTLLFAFANSYALLCVARGFQGIGSSFTMVPALGTLAQV 198

  Fly   294 YPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSLGLQLLTMDLTVQ 358
            :|::..|.|.||:.:..:|:|||.|.|||..:|:.:|||:||::::.|..|...||...:..|..
Frog   199 FPDDVERGKAMGLAMSGVAIGVLAGPPFGSAMYEFVGKSSPFLVIAALALLDGALQCCVLKPTKF 263

  Fly   359 PEVVVEDRPKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQYLKPNKWQLGTVFIPDSV 423
            ..:.|.:.| :|.||....|:...:.:.....:..::||.:||.:::.:....:|||..|:|..:
Frog   264 SPLSVPETP-YRVLLTDPYIVVAAVGLCICNFSFGIMEPTIPIRMMETMCSPPYQLGLAFLPCML 327

  Fly   424 GYFVGTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLPHFALGLGIGVIDAALVP 488
            .||:..|.|...|:|.|:.....|.::.:|::.:.:|.|..:..|:.|...:|:|.|:.:.::.|
Frog   328 AYFICLNLFAGFAHKIGRWLCIMIGMMALGISVLCLPLARNIFGLIAPQAGVGIGFGLFETSMFP 392

  Fly   489 LLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGGELAQTFGFAWLMRIVGI 553
            ::|..||.           ...|:||.:|||...::.:.|.|.|..||.:|:..||.|||.|:||
Frog   393 MMAHLVDI-----------RHTSNYGAIYAISDIALCIGYALGPSCGGAIAKAIGFTWLMVILGI 446

  Fly   554 FNMIYGPILVYL 565
            .|::|.|:.:.|
Frog   447 INLVYAPLFILL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	116/352 (33%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	101/319 (32%)
slc18a1	XP_012814578.1	MFS_SLC18A1_2_VAT1_2	21..459	CDD:340942	146/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D1371520at2759
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030