DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prt and slc18a1

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_021334159.1	Gene:	slc18a1 / 571483	-ID:	-	Length:	523	Species:	Danio rerio

Alignment Length:	526	Identity:	171/526 - (32%)
Similarity:	275/526 - (52%)	Gaps:	86/526 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVVLSLEDTSSFSKLGYRSGESPGGGHP 111
            |:..:|.:|||||||||||:|||:|.:|.:.|                     :::.::|    |
Zfish    10 LVLAVVCVALLLDNMLLTVVVPIIPAFLYATE---------------------HQAQKNP----P 49

  Fly   112 QLYISKHPIPGKSMVNFTLLQL-STEATTTTTSIATTTNSPHNSTSMQSPPKLTVGQSGGTNVTG 175
            ......||      .|.:||.| :|....|:.|:..|..|..:||:          ::.|.|
Zfish    50 TTPFEAHP------TNTSLLSLYNTTTYNTSVSLNFTNFSSASSTN----------ENLGVN--- 95

  Fly   176 IGHKSRNRKLASGHPPTHDNSSNDNSNKELT--LTQENGSIGLLLAMKALVQLIFNPIVGNASSK 238
                               :||.|...||.:  |..||..:|||.|.||:|||:.||.||..:::
Zfish    96 -------------------SSSADYGCKEDSDFLEGENVKVGLLFASKAMVQLLVNPFVGPLTNR 141

  Fly   239 FGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSACINICGMSLVAQHYPEEARRSKV 303
            .||.:|:..|...:.:|:::|....:|..|..||::||:||:...:.|:.::|..|.:::.|...
Zfish   142 IGYHIPMFAGFVIMFVSTIMFAFSGTYTLLFFARSLQGIGSSFSTVAGLGMLASVYTDDSERGIA 206

  Fly   304 MGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSLGLQLLTMDLTVQPEVV----VE 364
            |||.||.:|:|||:|.|||.|:|:.:.||:||::|:.|......|||..:    ||..:    :|
Zfish   207 MGIALGGLAMGVLIGAPFGSIMYEFVSKSSPFLVLAFLAMFDGALQLCIL----QPSKISPTSME 267

  Fly   365 DRPKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQYLKPNKWQLGTVFIPDSVGYFVGT 429
            ..|.: .||:...||....::.|:...:|:|||.||||::|.:...|||||..|:|.||.|.:||
Zfish   268 GTPLF-ILLKDPYILISAGSLCFANMGVAVLEPTLPIWMMQTMCAPKWQLGVAFLPASVSYLIGT 331

  Fly   430 NFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLPHFALGLGIGVIDAALVPLLATFV 494
            |.||.:|.|.|:...|.:.:.:||::.:.:|.|..:..|:.|:..||..:|::|.::..::...|
Zfish   332 NLFGILANKMGRWLCSMVGMFIVGISLLCVPFAKNLYGLIGPNGGLGFAVGMVDTSMFAIMGYLV 396

  Fly   495 DATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGGELAQTFGFAWLMRIVGIFNMIYG 559
            |.           ..:|.||:||||...::.:.:.:.|..||.|.:|.||..||.|:||.|::|.
Zfish   397 DI-----------RHVSVYGSVYAIADVALCVGFAVGPSTGGALVRTIGFPNLMVIIGIINILYA 450

  Fly   560 PILVYL 565
            |:..:|
Zfish   451 PLCFFL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	126/356 (35%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	111/323 (34%)
slc18a1	XP_021334159.1	MFS_1	117..423	CDD:311564	111/321 (35%)
slc18a1	XP_021334159.1	2_A_01_02	118..259	CDD:273318	56/144 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930