DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prt and slc18a2

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001243154.1	Gene:	slc18a2 / 553304	ZFINID:	ZDB-GENE-080514-1	Length:	515	Species:	Danio rerio

Alignment Length:	575	Identity:	191/575 - (33%)
Similarity:	304/575 - (52%)	Gaps:	100/575 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAV----VLSLEDTSSFSKLGYRSGE 104
            :|.||.:||::|||||||||||:|||:|.||.:::.:.:..|    :..|..:|:|..:
Zfish    22 SRRLILLIVFIALLLDNMLLTVVVPIIPSYLYTVDDEAAQMVKNHSMTPLSPSSTFQSI------ 80

  Fly   105 SPGGGHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSPHNSTSMQSPPKLTVGQSG 169
                  ..||.:...:.|.|.      |:||..   ..|:|.|..||.|.:..
Zfish    81 ------VSLYDNTTRVTGFSP------QMSTAG---PMSLAPTFVSPQNQSDC------------ 118

  Fly   170 GTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQENGSIGLLLAMKALVQLIFNPIVGN 234
                                 |..|:.          |..||..:|||.|.||.||||.||.:|.
Zfish   119 ---------------------PKADDQ----------LLNENVKVGLLFASKATVQLITNPFIGP 152

  Fly   235 ASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSACINICGMSLVAQHYPEEAR 299
            .:::.||::|:..|...:.:|:::|....||..|.:||::|||||:|.::.||.::|..|.::..
Zfish   153 LTNRIGYQIPMFAGFCIMFVSTIMFAFSSSYTLLFLARSLQGVGSSCSSVAGMGMLASVYTDDEE 217

  Fly   300 RSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSLGLQLLTMDLTVQPEVVVE 364
            |...:||.||.:|:|||:|.|||.::|:.:||:|||:||:.|..|...|||..:    ||..|..
Zfish   218 RGNAIGIALGGLAMGVLVGPPFGSVMYEFVGKTAPFLILAVLAVLDGALQLFVL----QPSKVEP 278

  Fly   365 DRPKWRS---LLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQYLKPNKWQLGTVFIPDSVGYF 426
            :..|..|   |::...||....:|.|:...:|||||.||||:::.:.|.|||||..|:|.|:.|.
Zfish   279 ESQKGTSLITLMKDPYILIAAGSICFANMAIAMLEPALPIWMMETMCPRKWQLGIAFVPASISYL 343

  Fly   427 VGTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLPHFALGLGIGVIDAALVPLLA 491
            :|||.|..:|:|.|:...|.|.:||||::.:.:|.|..:..|::|:|.:|..||::|::::|::.
Zfish   344 IGTNIFAVLAHKMGRWLCSLIGMLLVGISILCVPLAKDIYGLIVPNFGVGFAIGMVDSSMMPIMG 408

  Fly   492 TFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGGELAQTFGFAWLMRIVGIFNM 556
            ..||.           ..:|.||:||||...:..:.:.|.|..||.:|::.||.|||.|:|:.::
Zfish   409 YLVDL-----------RHVSVYGSVYAIADVAFCMGFALGPSAGGAIARSIGFPWLMTIIGLVDI 462

  Fly   557 IYGPILVYLHQKYDPKALREQHNDMLLQS---------SGRGSRYKQLYNSMDVE 602
            ::.|:..:|.   :|.| .|:...:|:.|         |.:||.| |:.:..|.|
Zfish   463 MFAPLCFFLR---NPPA-NEEKMAILMDSNCSMKTRSYSTQGSSY-QMGDDFDPE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	134/355 (38%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	122/322 (38%)
slc18a2	NP_001243154.1	MFS_1	132..438	CDD:284993	122/320 (38%)
		2_A_01_02	133..274	CDD:273318	61/144 (42%)
		MFS	295..>472	CDD:119392	68/187 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930