DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prt and Slc18a2

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_766111.1	Gene:	Slc18a2 / 214084	MGIID:	106677	Length:	517	Species:	Mus musculus

Alignment Length:	557	Identity:	180/557 - (32%)
Similarity:	290/557 - (52%)	Gaps:	105/557 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVV------LSLEDTSSFSKL---- 98
            :|.||..||:||||||||||||:|||:|.||.|::.:.::..:      |:...:.||..:
Mouse    18 SRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEIQTARPALTASTSESFHSIFSYY 82

  Fly    99 -------GYRSGESPGGGHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSPHNSTS 156
                   |..:|..|||..|                        :||||..::..||..|
Mouse    83 NNSTVFTGNATGGLPGGESP------------------------KATTTQHTVTNTTVPP----- 118

  Fly   157 MQSPPKLTVGQSGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQENGSIGLLLAMK 221
                                                      |..:::..|..||..:|||.|.|
Mouse   119 ------------------------------------------DCPSEDKDLLNENVQVGLLFASK 141

  Fly   222 ALVQLIFNPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSACINICG 286
            |.|||:.||.:|..:::.||.:|:..|...:.:|:::|....||..||:||::||:||:|.::.|
Mouse   142 ATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAG 206

  Fly   287 MSLVAQHYPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSLGLQLL 351
            |.::|..|.::..|...|||.||.:|:|||:|.|||.:||:.:||:|||::|:.|:.|...:||.
Mouse   207 MGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLF 271

  Fly   352 TMDLT-VQPEVVVEDRPKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQYLKPNKWQLG 415
            .:..: ||||  .:......:||:...||....:|.|:...:|||||.||||:::.:...|||||
Mouse   272 VLQPSRVQPE--SQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLG 334

  Fly   416 TVFIPDSVGYFVGTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLPHFALGLGIG 480
            ..|:|.|:.|.:|||.||.:|:|.|:...:.:.:::||::.:.||.|..:..|:.|:|.:|..||
Mouse   335 VAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIG 399

  Fly   481 VIDAALVPLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGGELAQTFGFA 545
            ::|::::|::...||.           ..:|.||:||||...:..:.|.:.|..||.:|:..||.
Mouse   400 MVDSSMMPIMGYLVDL-----------RHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFP 453

  Fly   546 WLMRIVGIFNMIYGPILVYLHQ---KYDPKALREQHN 579
            |||.|:||.::::.|:..:|..   |.:..|:...||
Mouse   454 WLMTIIGIIDIVFAPLCFFLRSPPAKEEKMAILMDHN 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	131/353 (37%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	118/320 (37%)
Slc18a2	NP_766111.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..119		8/89 (9%)
		MFS_1	133..440	CDD:284993	118/319 (37%)
		2_A_01_02	135..276	CDD:273318	59/140 (42%)
		MFS	297..>474	CDD:119392	66/187 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S3897
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.880