Protein Alignment prt and Slc18a3

DIOPT Version :9

• Sequence 1: NP_001097887.1
• Gene: prt / 117368
• FlyBaseID: FBgn0043005
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_068358.2
• Gene: Slc18a3 / 20508
• MGIID: 1101061
• Length: 530
• Species: Mus musculus
• Alignment Length: 587
• Identity: 160/587 - (27%)
• Similarity: 264/587 - (44%)
• Gaps: 110/587 - (18%)

  Fly    25 QLNAPGRRSSTPSGA---NGSSNRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVV 86
            |..|...:.|...||   .....|.|:.|||.:||||||||..|||||:|||:|.:...:.|..:
Mouse     9 QARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSESPTL 73

  Fly    87 LSLEDTSSFSKLGYRSGESPGGGHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSP 151
            :|                         .:.:..:|..::.|.:....:|.|:.|....|.:...|
Mouse    74 IS-------------------------EVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRP 113

  Fly   152 HNSTSMQSPPKLTVGQSGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQENGSIGL 216
            ...|.                                                    .|:..||:
Mouse   114 RYPTE----------------------------------------------------SEDVKIGV 126

  Fly   217 LLAMKALVQLIFNPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSAC 281
            |.|.||::||:.||:.|....:..|.:|:::|...:..|:::|...|.|..|..||::||:|||.
Mouse   127 LFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAF 191

  Fly   282 INICGMSLVAQHYPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSL 346
            .:..|::::|..||||..||:.:|:.|..|:.|.|:..|||||||:..||..||::|:.   :||
Mouse   192 ADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAA---VSL 253

  Fly   347 GLQLLTMDLTVQPEVVVEDR-------PKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLI 404
            ...||.:.:..........|       |..|.:|: ..|..:..|:......:|.|||.:..|:.
Mouse   254 FDALLLLAVAKPFSAAARARANLPVGTPIHRLMLD-PYIAVVAGALTTCNIPLAFLEPTIATWMK 317

  Fly   405 QYLKPNKWQLGTVFIPDSVGYFVGTNFFGSIAYKYGQVK--VSCISLLLVGVASILIPSATTVAQ 467
            ..:..::|::|.|::|..|.:.:|......:|.:|..::  ...:.|.::||:|.::|:..:.|.
Mouse   318 HTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAP 382

  Fly   468 LLLPHFALGLGIGVIDAALVPLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAP 532
            |::....|..||.::|.||:|.||..||.           ..:|.||:||||...|.|:||.|.|
Mouse   383 LVVSLCGLCFGIALVDTALLPTLAFLVDV-----------RHVSVYGSVYAIADISYSVAYALGP 436

  Fly   533 LIGGELAQTFGFAWLMRIVGIFNMIYGPILVYLHQKYDPKALREQHNDMLLQSSGRGSRYKQLYN 597
            ::.|.:..:.||..|...:|:.|::|.|:|:.| :............|:||....:|     ||:
Mouse   437 IVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLL-RNVGLLTRSRSERDVLLDEPPQG-----LYD 495

  Fly   598 SM 599
            :|
Mouse   496 AM 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	114/361 (32%)
		MFS_1	212..532	CDD:284993	104/328 (32%)
Slc18a3	NP_068358.2	MFS_1	124..436	CDD:284993	104/326 (32%)
		2_A_01_02	125..260	CDD:273318	54/137 (39%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000269|PubMed:17092608	471..530		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..530

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D406900at33208
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830