DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prt and Slc18a1

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_694694.1	Gene:	Slc18a1 / 110877	MGIID:	106684	Length:	521	Species:	Mus musculus

Alignment Length:	562	Identity:	183/562 - (32%)
Similarity:	286/562 - (50%)	Gaps:	89/562 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VQLNAPGRRSSTPSGANGSSNRCLIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVVLS 88
            |.|.||.|...     .|..:|.|:.|:|::|||||||||||:|||:|.:|.:.|
Mouse     4 VVLGAPQRLLK-----EGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATE---------- 53

  Fly    89 LEDTSSFSKLGYRSGESPGGGHPQLYISKHPIPGKSMVNFTLLQ---LSTEATTTTTSIATTTNS 150
            .:|                                  :|.:||:   :|::...|:.:.:||.:.
Mouse    54 FKD----------------------------------INSSLLRGPSVSSQQALTSPAFSTTFSF 84

  Fly   151 PHNST-SMQSPPKLTVGQSGGT---NVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQEN 211
            ..|:| :::......|....||   .||..|...:|..|....                .|.:||
Mouse    85 FDNTTMTVEEHVPFRVAWINGTIPPPVTEAGSVPKNNCLQGIE----------------FLEEEN 133

  Fly   212 GSIGLLLAMKALVQLIFNPIVGNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQG 276
            ..||:|.|.|||:||:.||.||..:::.||.:|:.||...:.||:|:|....:|..|.|||.:||
Mouse   134 VRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQG 198

  Fly   277 VGSACINICGMSLVAQHYPEEARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTL 341
            :||:..::.|:.::|..|.:...|.:.|||.||.:|||:|:|.|||.::|:.:|||:||:||:.|
Mouse   199 IGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFL 263

  Fly   342 MFLSLGLQL-LTMDLTVQPEVVVEDRPKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQ 405
            ..|...||. :.....|.||..:  .....:||:...||....:|..:...:|:|||.||||::|
Mouse   264 ALLDGALQFCILWPSKVSPESAM--GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQ 326

  Fly   406 YLKPNKWQLGTVFIPDSVGYFVGTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLL 470
            .:...:||||..|:|.||.|.:|||.||.:|.|.|:...|.:.::.||::.:.:|.|..:..|:.
Mouse   327 TMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIG 391

  Fly   471 PHFALGLGIGVIDAALVPLLATFVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIG 535
            |:..||..||::|::|:|::...||.           ...|.||:||||...:..:.:.:.|..|
Mouse   392 PNAGLGFAIGMVDSSLMPIMGYLVDL-----------RHTSVYGSVYAIADVAFCVGFAIGPSTG 445

  Fly   536 GELAQTFGFAWLMRIVGIFNMIYGPILVYLHQKYDPKALREQ 577
            |.:....||.|||.|:|..|:||.|:..:|.   :|.|..|:
Mouse   446 GVIVPVIGFPWLMVIIGTINIIYAPLCCFLQ---NPPAKEEE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	131/353 (37%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	117/320 (37%)
Slc18a1	NP_694694.1	MFS_SLC18A1_2_VAT1_2	127..475	CDD:340942	134/376 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3764
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920