DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prt and LOC100496053

DIOPT Version :9

Sequence 1:	NP_001097887.1	Gene:	prt / 117368	FlyBaseID:	FBgn0043005	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_002932792.2	Gene:	LOC100496053 / 100496053	-ID:	-	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	174/563 - (30%)
Similarity:	274/563 - (48%)	Gaps:	105/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LIAVIVYLALLLDNMLLTVIVPILPDYLASLEADTSSAVVLSLE-----DTSSFSK--LGYRSGE 104
            |:.|:|:|||||||:|||::||::||||...|....:||...:.     |:|||..  |.||..|
Frog    28 LVLVVVFLALLLDNLLLTIVVPVIPDYLYESEFVNKTAVEAKMSSIPAPDSSSFLSRLLYYRYNE 92

  Fly   105 SPGGGHPQLYISKHPIPGKSMVNFTLLQLSTEATTTTTSIATTTNSPHNSTS--MQSPPKLTVGQ 167
                   .|:..:|                                 .|||.  ::.|.:
Frog    93 -------LLFSDEH---------------------------------ENSTKGLLKEPCR----- 112

  Fly   168 SGGTNVTGIGHKSRNRKLASGHPPTHDNSSNDNSNKELTLTQENGSIGLLLAMKALVQLIFNPIV 232
                       |..|                       .|..||..:|||:|.|::|.::.||||
Frog   113 -----------KDTN-----------------------FLRDENVPVGLLIASKSMVHILVNPIV 143

  Fly   233 GNASSKFGYRLPIVVGTFFLLLSSLVFTVGESYWALLVARAVQGVGSACINICGMSLVAQHYPEE 297
            ...:::.||.||:..|...:|:|..:|..|.||..||:||.:||:||:...:.|:.:||..|.::
Frog   144 SLFTNRVGYGLPMFFGFLIMLMSIFMFAFGGSYVFLLLARMLQGIGSSFTVVAGLGMVASIYTDD 208

  Fly   298 ARRSKVMGIILGSIALGVLLGYPFGGILYDLMGKSAPFIILSTLMFLSLGLQLLTMDLTVQPEVV 362
            .:|.|.|||.||.:.|||:.|.|||..||:.:||::||:.|:.|..|...|||..:...:.|.|.
Frog   209 YQRGKAMGIALGGVVLGVVAGPPFGSALYEFVGKASPFLFLAALALLDGALQLFILTPKISPAVT 273

  Fly   363 VEDRPKWRSLLECKMILAIVLAIWFSTSTMAMLEPCLPIWLIQYLKPNKWQLGTVFIPDSVGYFV 427
            ..  |.:.|||:...||.....:..::..:.||||.||||::..:....||:|.||:|.|:.|.|
Frog   274 TP--PSFCSLLKDPYILVAAGCLCIASMGIGMLEPTLPIWMLGSMCSPDWQIGLVFLPASLSYLV 336

  Fly   428 GTNFFGSIAYKYGQVKVSCISLLLVGVASILIPSATTVAQLLLPHFALGLGIGVIDAALVPLLAT 492
            .||.||.:::|:|:...|.:.::|:|:..:.:|.|..:..|:.|...:|:.:|::|::::|::..
Frog   337 CTNVFGILSHKFGRWLCSLLGMVLLGICLLCMPLAFNILGLIAPIAGIGVSLGIVDSSIMPIMGY 401

  Fly   493 FVDATLAQEDQGEGSSSMSSYGTVYAIQQTSVSLAYCLAPLIGGELAQTFGFAWLMRIVGIFNMI 557
            .||.           ...|.||.||||...:.|..|.:.|...|.:|:..||..||.|:|:.|:|
Frog   402 LVDL-----------RHSSVYGGVYAISDIAFSFGYAIGPSAAGAIAKAIGFPMLMVIIGVLNII 455

  Fly   558 YGPILVYLHQKYDPKALREQHNDMLLQSSGRGSRYKQLYNSMD 600
            |.|:.|.|..    ..::|:...:|...|...||..:...:.|
Frog   456 YCPLCVLLRN----PPMKEERRALLNHESIVPSRLMKKSQTQD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prt	NP_001097887.1	MFS	212..565	CDD:119392	126/352 (36%)
prt	NP_001097887.1	MFS_1	212..532	CDD:284993	112/319 (35%)
LOC100496053	XP_002932792.2	MFS_SLC18A1_2_VAT1_2	116..464	CDD:340942	130/383 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59108
OrthoDB	1	1.010	-	-		D1371520at2759
OrthoFinder	1	1.000	-	-		FOG0000700
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23506
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030