DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-Q and PIGQ

DIOPT Version :9

Sequence 1:	NP_001285323.1	Gene:	PIG-Q / 117366	FlyBaseID:	FBgn0086448	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_683721.1	Gene:	PIGQ / 9091	HGNCID:	14135	Length:	760	Species:	Homo sapiens

Alignment Length:	410	Identity:	106/410 - (25%)
Similarity:	181/410 - (44%)	Gaps:	103/410 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 IKVILYDKQMVRNLFVSGESENRRSLEYNDNDSTDCDFLELSRLNQPTADNQNKANNNANKSIQY 171
            :.:|.||::.|.                            ||:|:.||.....:|  .|..:...
Human   126 VMLIFYDQRQVL----------------------------LSQLHLPTVLPDRQA--GATTASTG 160

  Fly   172 GLTLIADS----------------PIKIFEYMAENV---------------------FINSIMVH 199
            ||..:.|:                |:::..:.:|.|                     .:.|::..
Human   161 GLAAVFDTVARSEVLFRSDRFDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSA 225

  Fly   200 TTIYKHFKEWQ--------TACD--------------------------KRSRPANIVLDRILGI 230
            .:..:.||.|.        :.|:                          |.:..|:::||..||:
Human   226 VSACRVFKLWPLSFLGSKLSTCEQLRHRLEHLTLIFSTRKAENPAQLMRKANTVASVLLDVALGL 290

  Fly   231 ILMLILF--TLATQPGDFLIQISHYVIDELYGLLKVLEGSPIGLKLNIHLNNFFLDCFKYHIELW 293
            :|:..|.  :......|.|:.::.:|.:||..||:.|.|:|.|||:|..|:......|.|||.||
Human   291 MLLSWLHGRSRIGHLADALVPVADHVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLW 355

  Fly   294 STFLDFIEPLVRQVFLAIGMIGCLGFTFQIALLVDLISVIGLHSHCFYIYTKVLYNVERRGLSVL 358
            .:::..:.|.|..:...:|:..|||.|..::||.|:|:::..|.:|||:|...||.::..|||.|
Human   356 ISYIHLMSPFVEHILWHVGLSACLGLTVALSLLSDIIALLTFHIYCFYVYGARLYCLKIHGLSSL 420

  Fly   359 WQVVRGNRYNILKGRTESHNYMNRQLYLATIFFSAILFLLPTTLVYYIVFAALKALTFATLSVFH 423
            |::.||.::|:|:.|.:|.:|...||::.|:.|:.:|||||||.:||:||..|:.|..|...:.|
Human   421 WRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILLFLLPTTALYYLVFTLLRLLVVAVQGLIH 485

  Fly   424 FLRRKLMYLPIEVCIKRLLR 443
            .|...:..||:.....||.|
Human   486 LLVDLINSLPLYSLGLRLCR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-Q	NP_001285323.1	Gpi1	240..401	CDD:282831	60/160 (38%)
PIGQ	NP_683721.1	Gpi1	277..449	CDD:309941	60/171 (35%)
PIGQ	NP_683721.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152973
Domainoid	1	1.000	137	1.000	Domainoid score	I4910
eggNOG	1	0.900	-	-		E1_KOG1183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247641at2759
OrthoFinder	1	1.000	-	-		FOG0005188
OrthoInspector	1	1.000	-	-		oto90562
orthoMCL	1	0.900	-	-		OOG6_103823
Panther	1	1.100	-	-	LDO	PTHR21329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3702
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.710