DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and SKI7

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_014719.1	Gene:	SKI7 / 854243	SGDID:	S000005602	Length:	747	Species:	Saccharomyces cerevisiae

Alignment Length:	742	Identity:	167/742 - (22%)
Similarity:	292/742 - (39%)	Gaps:	165/742 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ISKNKDIQEEEAD-EDEDEDAAFAKARRDSESFQMPQLDEIEQAKLSSCVDEVRSVVGDAVSERR 119
            :.||::.::..|: :.:|.....||.:.....|...|    ....||..:..::....|...:.:
Yeast    37 LHKNRETKDNNAETKRKDLKTLLAKDKVKRSDFTPNQ----HSVSLSLKLSALKKSNSDLEKQGK 97

  Fly   120 IVETSMKFDY--DMQKILDEILN-EETNKSAK-----------PAVNKMKAPAAPVL-----PKT 165
            .|....|.:.  ..:|..|:.|| ||:.|:.|           |.:|:....|....     ..:
Yeast    98 SVTLDSKENELPTKRKSPDDKLNLEESWKAIKEMNHYCFLKNDPCINQTDDFAFTNFIIKDKKNS 162

  Fly   166 VSKTVPTPPPK---ISLKEPRR---GFEIPS--PKVPSSPVVSGRNTPVDISAGDDISRSS---- 218
            :|.::|.....   :|||:...   |..:|.  ||......:...|.|    :.|||.:|:
Yeast   163 LSTSIPLSSQNSSFLSLKKHNNELLGIFVPCNLPKTTRKVAIENFNRP----SPDDIIQSAQLNA 223

  Fly   219 ----------ATVFKVSKEQAVRNARQLYEKERADQKSHI--H-----MIVIGHVDAGKSTLMGH 266
                      .:|.|..|::.:.  .|....|..|..|.|  |     .:.:|..:||||||:||
Yeast   224 FNEKLENLNIKSVPKAEKKEPIN--LQTPPTESIDIHSFIATHPLNLTCLFLGDTNAGKSTLLGH 286

  Fly   267 LLYDTGNVSQRVMHKHEQESKKLG-KQSFMYAWVLDETGEERARGITMDVGQSRIET----KTKI 326
            ||||...:|...|.:.:::|..|. ..|..:..:||.|..||..|.:|.....::|.    .:..
Yeast   287 LLYDLNEISMSSMRELQKKSSNLDPSSSNSFKVILDNTKTERENGFSMFKKVIQVENDLLPPSST 351

  Fly   327 VTLLDAPG-----HKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQTREHAIL--VRSLG 384
            :||:|.||     :|:.:.::::  ...:|.:||:|.....:|...: |...:.:.||  :..|.
Yeast   352 LTLIDTPGSIKYFNKETLNSILT--FDPEVYVLVIDCNYDSWEKSLD-GPNNQIYEILKVISYLN 413

  Fly   385 VN-----QLGVVINKLDTVGWSQDRFTEIVTKLKSFLKLAGFK--DSDVSFTPCSGLTGENLTK- 441
            .|     .|.:::||.|.:.|.:.|...|.::|...|| ..|:  |::..|.|||||.|.||.|
Yeast   414 KNSACKKHLIILLNKADLISWDKHRLEMIQSELNYVLK-ENFQWTDAEFQFIPCSGLLGSNLNKT 477

  Fly   442 --------KAQEPALT---NWYSG------RHLLDVIENFKIPERAIDRPLRMSVSDIYKGT--- 486
                    |::..::.   .||.|      .:|| |..|....|..::.|.   |..|.:.:
Yeast   478 ENITKSKYKSEFDSINYVPEWYEGPTFFSQLYLL-VEHNMNKIETTLEEPF---VGTILQSSVLQ 538

  Fly   487 --------------GSGFCISGR---VETGVLCLNDKVLVGASREQAQV-KSLTMNEFPQTCVFA 533
                          .||:..||:   :.|.....:...:|...:...|: ::.|.|.     :..
Yeast   539 PIAEINYVSLKVLINSGYIQSGQTIEIHTQYEDFHYYGIVSRMKNSKQILETNTKNN-----ISV 598

  Fly   534 GDQVSVTLPALDINN----------VTVGCII-----SDPQTP-IPVTTRFQA-RIIVFNVKV-- 579
            |....:....:.|:|          :..|.||     ::..:| :|.|.:..| |:|..:::.
Yeast   599 GLNPDILEVLVKIHNTEDFTKKQFHIRKGDIIIHSRKTNTLSPNLPNTLKLLALRLIKLSIQTHA 663

  Fly   580 ---PITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIE 641
               |:.:|..:||:| :|...||  ||...:  .|.::      .:..|...:||:|...|....
Yeast   664 LSDPVDLGSELLLYH-NLTHNAV--KLVKIL--GTNDI------SINPNQSLIVEVEIIEPDFAL 717

  Fly   642 RYADFKELGR--VMLRVAGVTIAAGMV 666
            ...|.|.:..  |:..:....||.|.:
Yeast   718 NVIDSKYITNNIVLTSIDHKVIAVGRI 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	13/64 (20%)
		TEF1	241..669	CDD:227581	123/515 (24%)
		EF1_alpha	249..468	CDD:206670	73/260 (28%)
		HBS1-like_II	474..557	CDD:293912	18/118 (15%)
		HBS1_C_III	561..669	CDD:294008	28/115 (24%)
SKI7	NP_014719.1	TEF1	261..747	CDD:227581	121/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900