Protein Alignment HBS1 and HBS1

DIOPT Version :10

• Sequence 1: NP_652729.2
• Gene: HBS1 / 117365
• FlyBaseID: FBgn0042712
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_013010.3
• Gene: HBS1 / 853959
• SGDID: S000001792
• Length: 611
• Species: Saccharomyces cerevisiae
• Alignment Length: 604
• Identity: 194/604 - (32%)
• Similarity: 291/604 - (48%)
• Gaps: 116/604 - (19%)

  Fly   127 FD--YDMQKILDEILNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPRRGFEIP 189
            ||  :|::..|.|:         |..:.|.|.|..|:.....|..|......||:.:.|....:|
Yeast    61 FDNNFDLESTLAEL---------KKTLKKKKTPKKPIAAANGSANVTQKLANISISQQRPNDRLP 116

  Fly   190 ---------------------------SPKVPSSPVVSGRNTPVDISAGDDISRSSATVFKVSKE 227
                                       ...||:.|     ..|.||||
Yeast   117 DWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKP-----KKPHDISA----------------- 159

  Fly   228 QAVRNARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQ 292
             .|::|           ..|:..:|:||||||||||||.||||...|:|..:.|.::||:.:||.
Yeast   160 -FVKSA-----------LPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKS 212

  Fly   293 SFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVD 357
            ||.:||::|:|.|||.||:|:.:..|...|.....|::|||||:||:||.|.|.:|||:|:|.||
Yeast   213 SFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVD 277

  Fly   358 ATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTVGWSQDRFTEIVTKLKSFLKLAGFK 422
            .:...|||||:|.|||:||.:|..|||::.|.:.:||:|.|.|||.||.||.:||..:|...||.
Yeast   278 CSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQRFEEIKSKLLPYLVDIGFF 342

  Fly   423 DSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIEN--FKIPER----AIDRPLRMSVSD 481
            :.::::.|.||.:||.:.|......:..||:|.:|:..:||  |||.:.    ..|.|...||.:
Yeast   343 EDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISKENEGINKDDPFLFSVLE 407

  Fly   482 IY--KGTGSGFC-ISGRVETGVL--------------CLNDKVLVGASREQAQVKSLTMNEFPQT 529
            |.  |.|.:... :||::|:|.:              |:.||:.||:.:.|:     |.:|....
Yeast   408 IIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQS-----TNHEETDV 467

  Fly   530 CVFAGDQVSVTLPAL---DINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHH 591
            .: .||.|::.|...   ||.|..:...:.  .:.|.....|...:..|::..|:..|.|.:|..
Yeast   468 AI-KGDFVTLKLRKAYPEDIQNGDLAASVD--YSSIHSAQCFVLELTTFDMNRPLLPGTPFILFI 529

  Fly   592 QSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYA------DFKELG 650
            ....:||.:.:|.:.|.|. ....|||.|.||:...|.||:|.   |.::|:.      :...||
Yeast   530 GVKEQPARIKRLISFIDKG-NTASKKKIRHLGSKQRAFVEIEL---IEVKRWIPLLTAHENDRLG 590

  Fly   651 RVMLRVAGVTIAAGMVTKI 669
            ||:||..|.|||||.:::|
Yeast   591 RVVLRKDGRTIAAGKISEI 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_652729.2	HBS1_N	83..148	CDD:462642	5/22 (23%)
		TEF1	242..669	CDD:444074	167/458 (36%)
HBS1	NP_013010.3	HBS1_N	5..73	CDD:462642	5/13 (38%)
		TEF1	166..611	CDD:444074	169/470 (36%)
		EF1_alpha	169..383	CDD:206670	96/213 (45%)