DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and HBS1

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_013010.3	Gene:	HBS1 / 853959	SGDID:	S000001792	Length:	611	Species:	Saccharomyces cerevisiae

Alignment Length:	604	Identity:	194/604 - (32%)
Similarity:	291/604 - (48%)	Gaps:	116/604 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 FD--YDMQKILDEILNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPRRGFEIP 189
            ||  :|::..|.|:         |..:.|.|.|..|:.....|..|......||:.:.|....:|
Yeast    61 FDNNFDLESTLAEL---------KKTLKKKKTPKKPIAAANGSANVTQKLANISISQQRPNDRLP 116

  Fly   190 ---------------------------SPKVPSSPVVSGRNTPVDISAGDDISRSSATVFKVSKE 227
                                       ...||:.|     ..|.||||
Yeast   117 DWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKP-----KKPHDISA----------------- 159

  Fly   228 QAVRNARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQ 292
             .|::|           ..|:..:|:||||||||||||.||||...|:|..:.|.::||:.:||.
Yeast   160 -FVKSA-----------LPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKS 212

  Fly   293 SFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVD 357
            ||.:||::|:|.|||.||:|:.:..|...|.....|::|||||:||:||.|.|.:|||:|:|.||
Yeast   213 SFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVD 277

  Fly   358 ATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTVGWSQDRFTEIVTKLKSFLKLAGFK 422
            .:...|||||:|.|||:||.:|..|||::.|.:.:||:|.|.|||.||.||.:||..:|...||.
Yeast   278 CSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQRFEEIKSKLLPYLVDIGFF 342

  Fly   423 DSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIEN--FKIPER----AIDRPLRMSVSD 481
            :.::::.|.||.:||.:.|......:..||:|.:|:..:||  |||.:.    ..|.|...||.:
Yeast   343 EDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISKENEGINKDDPFLFSVLE 407

  Fly   482 IY--KGTGSGFC-ISGRVETGVL--------------CLNDKVLVGASREQAQVKSLTMNEFPQT 529
            |.  |.|.:... :||::|:|.:              |:.||:.||:.:.|:     |.:|....
Yeast   408 IIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQS-----TNHEETDV 467

  Fly   530 CVFAGDQVSVTLPAL---DINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHH 591
            .: .||.|::.|...   ||.|..:...:.  .:.|.....|...:..|::..|:..|.|.:|..
Yeast   468 AI-KGDFVTLKLRKAYPEDIQNGDLAASVD--YSSIHSAQCFVLELTTFDMNRPLLPGTPFILFI 529

  Fly   592 QSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYA------DFKELG 650
            ....:||.:.:|.:.|.|. ....|||.|.||:...|.||:|.   |.::|:.      :...||
Yeast   530 GVKEQPARIKRLISFIDKG-NTASKKKIRHLGSKQRAFVEIEL---IEVKRWIPLLTAHENDRLG 590

  Fly   651 RVMLRVAGVTIAAGMVTKI 669
            ||:||..|.|||||.:::|
Yeast   591 RVVLRKDGRTIAAGKISEI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	5/19 (26%)
		TEF1	241..669	CDD:227581	167/459 (36%)
		EF1_alpha	249..468	CDD:206670	104/220 (47%)
		HBS1-like_II	474..557	CDD:293912	25/102 (25%)
		HBS1_C_III	561..669	CDD:294008	36/113 (32%)
HBS1	NP_013010.3	HBS1_N	11..73	CDD:401037	5/13 (38%)
HBS1	NP_013010.3	TEF1	161..611	CDD:227581	170/475 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68525
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103149
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640