DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HBS1 and eef1a1l2

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001035074.1	Gene:	eef1a1l2 / 664756	ZFINID:	ZDB-GENE-050706-188	Length:	462	Species:	Danio rerio

Alignment Length:	446	Identity:	162/446 - (36%)
Similarity:	254/446 - (56%)	Gaps:	28/446 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 QKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERA 308
            :|.||:::||||||:||||..|||:|..|.:.:|.:.|.|:|:.::||.||.||||||:...||.
Zfish     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68

  Fly   309 RGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQT 373
            ||||:|:...:.||....||::|||||:|||.|||:|.:|||.|:|:|.|..||||:|....|||
Zfish    69 RGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQT 133

  Fly   374 REHAILVRSLGVNQLGVVINKLDTV--GWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGLTG 436
            ||||:|..:|||.||.|.:||:|:.  .:||.||.||..::.:::|..|:..:.|:|.|.||..|
Zfish   134 REHALLAYTLGVKQLIVGVNKMDSTEPPYSQARFEEITKEVSAYIKKIGYNPATVAFVPISGWHG 198

  Fly   437 ENLTKKAQEPALT-NWY------------SGRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTGS 488
            :|:.    ||:.. .|:            :|..||:.:::...|.|..|:|||:.:.|:||..|.
Zfish   199 DNML----EPSSNMGWFKGWKIERKEGGANGVTLLEALDSILPPSRPTDKPLRLPLQDVYKIGGI 259

  Fly   489 GFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGC 553
            |....||||||.|.....|.........:|||:.|:....|....||.|...:..:.:.::..|.
Zfish   260 GTVPVGRVETGTLKAGMIVTFAPVNVTTEVKSVEMHHESLTEALPGDNVGFNVKNVSVKDIRRGN 324

  Fly   554 IISDPQTPIPV-TTRFQARIIVFNVKVPITMGF-PVLLHHQSLIEPAVVCK---LTASIHKSTGE 613
            :..|.:...|: ...|.:::|:.|....|:.|: |||..|.:    .:.||   |...|.:.:|:
Zfish   325 VAGDSKNDPPMEAANFTSQVIILNHPGQISQGYAPVLDCHTA----HIACKFAELKEKIDRRSGK 385

  Fly   614 VVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            .::..|:.|.:...|::.:...:|:|:|.::.:..|||..:|....|:|.|::..:
Zfish   386 KLEDNPKALKSGDAAIILMIPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKAV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	162/444 (36%)
		EF1_alpha	249..468	CDD:206670	102/233 (44%)
		HBS1-like_II	474..557	CDD:293912	25/82 (30%)
		HBS1_C_III	561..669	CDD:294008	28/112 (25%)
eef1a1l2	NP_001035074.1	PTZ00141	1..460	CDD:185474	162/446 (36%)
		EF1_alpha	9..238	CDD:206670	102/232 (44%)
		EF1_alpha_II	242..332	CDD:293894	27/89 (30%)
		EF1_alpha_III	335..438	CDD:294004	27/106 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010