Protein Alignment HBS1 and Hbs1l

DIOPT Version :10

• Sequence 1: NP_652729.2
• Gene: HBS1 / 117365
• FlyBaseID: FBgn0042712
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001416141.1
• Gene: Hbs1l / 56422
• MGIID: 1891704
• Length: 685
• Species: Mus musculus
• Alignment Length: 711
• Identity: 329/711 - (46%)
• Similarity: 450/711 - (63%)
• Gaps: 73/711 - (10%)

  Fly     1 MSRHRIVRTMDYNDEYDGYDDIYGHSVEDEHCISPTDAQQWLYDRARGQQSISAFISKNKDIQEE 65
            |:|||.||..:|:::::. ||:||.||||::||||:.|.|::|.|.
Mouse     1 MARHRNVRGYNYDEDFED-DDLYGQSVEDDYCISPSTAAQFIYSRR------------------- 45

  Fly    66 EADEDEDEDAAFAKARRDSESFQMPQLDEIEQAKLSSCVDEVRSVVGDAVSERRIVETSMKFDYD 130
               ::.:|:..:...|..|.|....||.||:||:|.||:|.:|.|:||||.:..:.|..:|..:|
Mouse    46 ---DNPEEEYGYEDLRESSNSLLNHQLSEIDQARLYSCLDHMREVLGDAVPDDILTEAILKHKFD 107

  Fly   131 MQKILDEILNEE-----TNKS-----------AKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISL 179
            :||.|..:|.::     ..||           .|..:::.....:.::||....||       |.
Mouse   108 VQKALSVVLEQDGVQPWKEKSERAVCAGQPSKGKSVISRSSQSESEIVPKVAKMTV-------SG 165

  Fly   180 KEPRRGFEIP--------------------------SPKVPSSPVVSGRNTPVDISAGDDISRSS 218
            |:...|||:|                          ||.:|.:........|..:...:::..:.
Mouse   166 KKQTMGFEVPGLTSEENGLSVRAPHKGPPGDDVSVASPNIPETGTPKSALPPPSLQTSEELGSTP 230

  Fly   219 ATVFKVSKEQAVRNARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHE 283
            ..|.|..|.:...:.:...|| |...|..::::|||||||||||||||:||..|||::|.|||:|
Mouse   231 TPVRKSGKLRQQIDVKAELEK-RQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNVNKRTMHKYE 294

  Fly   284 QESKKLGKQSFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQ 348
            |||||.||.||.||||||||||||.||:|||||.::.||.||::||:|||||||||||||:||.|
Mouse   295 QESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQ 359

  Fly   349 ADVALLVVDATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTVGWSQDRFTEIVTKLK 413
            ||||:|||||:|||||:|||.|||||||.:|||||||.||.|.:||:|.|.|.|:||.||..||.
Mouse   360 ADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLG 424

  Fly   414 SFLKLAGFKDSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRMS 478
            .|||.||||:|||:|.|.|||:|||||.::|...||.||.|..||:.|::||.|:|:||:|.|:.
Mouse   425 HFLKQAGFKESDVAFIPTSGLSGENLTARSQSSDLTTWYKGMCLLEQIDSFKPPQRSIDKPFRLC 489

  Fly   479 VSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPA 543
            |||::|..|||||::|::|.|.:...|::|.....|....|.:|:::.|.....|||.|::||..
Mouse   490 VSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVNLTLVG 554

  Fly   544 LDINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIH 608
            :||..:.||||...|:.||...|||:|||:|||::||||.|||||||:|::.||||:.:|.:.::
Mouse   555 MDIIKINVGCIFCGPKEPIKACTRFRARILVFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLN 619

  Fly   609 KSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            ||||||.||||:.|.....|||||:|.||:.:|.|.|||||||.|||..|.|:|||:||::
Mouse   620 KSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEV 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_652729.2	HBS1_N	83..148	CDD:462642	27/80 (34%)
		TEF1	242..669	CDD:444074	256/426 (60%)
Hbs1l	NP_001416141.1	HBS1_N	45..123	CDD:462642	27/99 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..154		2/25 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..239		11/72 (15%)
		TEF1	259..680	CDD:444074	255/420 (61%)
		G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	265..272		6/6 (100%)
		G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	321..325		2/3 (67%)
		G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	342..345		2/2 (100%)
		G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	404..407		2/2 (100%)
		G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	443..445		1/1 (100%)