DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and gspt1

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001015805.2	Gene:	gspt1 / 548522	XenbaseID:	XB-GENE-955565	Length:	573	Species:	Xenopus tropicalis

Alignment Length:	551	Identity:	195/551 - (35%)
Similarity:	304/551 - (55%)	Gaps:	34/551 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 ETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKE----PRRGFEIPSPKVPS-----SP 197
            :.|.:|||.|..:.  ||..:|..:..:.|:...:...::    |..|.::..|.|.:     ||
Frog    29 QLNVNAKPFVPNVH--AAEFVPSFLRDSAPSDGQEEEEEQQGSCPTVGMDVAEPVVENGETEMSP 91

  Fly   198 VVS--GRNTPVDI-----SAGDDISRSSATVFKVSKEQAVRNARQLYEKERADQKSHIHMIVIGH 255
            ..|  .:..|::.     |.||..:........:.:|:.:...:.:.....|.:|.|::::.|||
Frog    92 EESWDHKEEPIEAEPGGGSEGDGGTTEEGASEMMEEEEDIPKPKTIVVPPDAPKKEHVNVVFIGH 156

  Fly   256 VDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERARGITMDVGQSRI 320
            |||||||:.|.::|.||.|.:|.:.|:|:|:|:..::::..:|.||...|||.:|.|::||::..
Frog   157 VDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYF 221

  Fly   321 ETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQTREHAILVRSLGV 385
            ||:.|..|:|||||||.|:||||.||:|||:|:||:.|.:||||:|||.||||||||:|.::.||
Frog   222 ETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGV 286

  Fly   386 NQLGVVINKLD--TVGWSQDRFTEIVTKLKSFLKLAGFK-DSDVSFTPCSGLTGENLTKKAQEPA 447
            ..|.|:|||:|  ||.||.||:.|...||..|||..||. ..|:.|.|||||||.||    :||.
Frog   287 KHLIVLINKMDDPTVNWSNDRYEECKEKLVPFLKKVGFNPKKDIYFMPCSGLTGANL----KEPV 347

  Fly   448 -LTNWYSGRHL---LDVIENFKIPERAIDRPLRMSVSDIYKGTGSGFCISGRVETGVLCLNDKVL 508
             ...||.|...   ||.:.||   .|::|.|:|:.:.|.||..|:  .:.|::|:|.:|...::.
Frog   348 EACPWYIGLPFIPYLDSLPNF---NRSVDGPVRLPIVDKYKDMGT--VVLGKLESGSICKGQQLT 407

  Fly   509 VGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCIISDPQTPIPVTTRFQARII 573
            :..::...:|.||..:|.....|..|:.:.:.|..::...:..|.|:.||.........|.|:|:
Frog   408 MMPNKHTVEVLSLLSDEVETELVAPGENLKLRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIV 472

  Fly   574 VFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPI 638
            :...|..|..|:..:||..:.||...:..|...:.|.:||..|.:||.:..:...:..|.|:..|
Frog   473 IIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTI 537

  Fly   639 CIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            |:|.:.||.::||..||..|.|||.|.|.|:
Frog   538 CLETFKDFPQMGRFTLRDEGKTIAIGKVLKL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	0/2 (0%)
		TEF1	241..669	CDD:227581	173/434 (40%)
		EF1_alpha	249..468	CDD:206670	113/225 (50%)
		HBS1-like_II	474..557	CDD:293912	19/82 (23%)
		HBS1_C_III	561..669	CDD:294008	34/107 (32%)
gspt1	NP_001015805.2	TEF1	146..570	CDD:227581	173/432 (40%)
		EF1_alpha	150..366	CDD:206670	111/219 (51%)
		eRF3_II	375..456	CDD:293906	19/82 (23%)
		eRF3_C_III	462..568	CDD:294003	34/105 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010