DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HBS1 and 42Sp50

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001011438.1	Gene:	42Sp50 / 496924	XenbaseID:	XB-GENE-5853280	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	452	Identity:	163/452 - (36%)
Similarity:	254/452 - (56%)	Gaps:	32/452 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 ERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETG 304
            ::..||:|:::::|||||:||||..|||:|..|....|.:.|.|..:.:|||.||.:||:||:..
Frog     3 DKTPQKTHLNVVIIGHVDSGKSTTTGHLIYKCGGFDPRALEKVEAAAAQLGKGSFKFAWILDKLK 67

  Fly   305 EERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFEL 369
            .||.||||:|:...:.:|....:|::|||||:|||.|||:|.:|||||||||.|..||||:|...
Frog    68 AERERGITIDISLWKFQTNRFTITIIDAPGHRDFIKNMITGTSQADVALLVVSAATGEFEAGVSR 132

  Fly   370 GGQTREHAILVRSLGVNQLGVVINKLDTVG--WSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCS 432
            .|||||||:|..::||.|:.|.:||:|...  :|..||.|:|..:..:||..|:..:.:.|.|.|
Frog   133 NGQTREHALLAYTMGVKQMIVCVNKMDLTDPPYSHKRFDEVVRNVTVYLKKIGYNPTTIPFVPVS 197

  Fly   433 GLTGENLTKKAQEPALTNWY------------SGRHLLDVIENFKIPERAIDRPLRMSVSDIYKG 485
            |.||||::..:|:   ..|:            .|:.||:|::....|.|..::|||:.:.|:||.
Frog   198 GWTGENISSPSQK---MGWFKGWKVKRKDGFTKGQSLLEVLDALVPPVRPANKPLRLPLQDVYKI 259

  Fly   486 TGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVT 550
            .|.|....|::|||:|.....:....|...|:|||:.|:..|....|.|..|...:..:.:.::.
Frog   260 GGIGTVPVGKIETGILKPGMTITFAPSGFAAEVKSIEMHHEPLQTAFPGFNVGFNVKNIAVKSLK 324

  Fly   551 VGCII----SDPQTPIPVTTRFQARIIVFNVKVPITMGF-PVLLHHQSLIEPAVVCKLT---ASI 607
            .|.:.    |||.|.   .:.|.|::|:.|....|..|: ||:..|.:    .:.|:.|   ..|
Frog   325 RGNVAGNSKSDPPTE---ASSFTAQVIILNHPGLIKAGYSPVIDCHTA----HITCQFTELQEKI 382

  Fly   608 HKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            .:.||:.::..|..|.:...|::.|:..:|.|:||:.|:..|||...|....|:|.|:|..:
Frog   383 DRRTGKKLEDNPGVLKSGDAAIITLKPIKPFCVERFFDYPPLGRFAARDLKQTVAVGVVKSV 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	163/449 (36%)
		EF1_alpha	249..468	CDD:206670	99/232 (43%)
		HBS1-like_II	474..557	CDD:293912	24/86 (28%)
		HBS1_C_III	561..669	CDD:294008	31/111 (28%)
42Sp50	NP_001011438.1	PTZ00141	7..447	CDD:185474	163/448 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920