DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HBS1 and gspt1

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001003992.1	Gene:	gspt1 / 445485	ZFINID:	ZDB-GENE-040822-36	Length:	564	Species:	Danio rerio

Alignment Length:	632	Identity:	199/632 - (31%)
Similarity:	309/632 - (48%)	Gaps:	110/632 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QEE--EADEDEDEDAAFAKARRDSESFQMPQLDEIEQAKLSSCVDEVRSVVGDAVSERRIVETSM 125
            ||:  ||..|.:..:||.....::..| :|..       ||      |....:|.|:...|..||
Zfish    13 QEDDVEATADTELQSAFTGLNVNAPEF-VPSF-------LS------RGPPENATSDGTDVVASM 63

  Fly   126 KFDYDMQKILDEILNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPRRGF---- 186
                ::.:.:..:.|.||:.||.....:...|                    ..:||..|.
Zfish    64 ----EISEPVGAVENGETDASAVETWEQKGEP--------------------DKEEPGGGSPADT 104

  Fly   187 ----------------EIPSPKVPSSPVVSGRNTPVDISAGDDISRSSATVFKVSKEQAVRNARQ 235
                            |:|:||:|..|
Zfish   105 GCFGDEAQDEMMEEDEEMPTPKLPPPP-------------------------------------- 131

  Fly   236 LYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVL 300
                ..|.:|.|::::.||||||||||:.|.::|.||.|.:|.:.|:|:|:|:..::::..:|.|
Zfish   132 ----PDAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVEKRTLEKYEREAKEKNRETWYLSWAL 192

  Fly   301 DETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFES 365
            |...|||.:|.|::||::..||:.|..|:|||||||.|:||||.||:|||:|:||:.|.:||||:
Zfish   193 DTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFET 257

  Fly   366 GFELGGQTREHAILVRSLGVNQLGVVINKLD--TVGWSQDRFTEIVTKLKSFLKLAGFK-DSDVS 427
            |||.||||||||:|.::.||..|.|:|||:|  ||.||.||:.|...||..|||..||. ..|:.
Zfish   258 GFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSLDRYEECKEKLVPFLKKVGFNPKKDIH 322

  Fly   428 FTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTGSGFCI 492
            |.|||||||.||.:.:.   |..||:|...:..:::..|..|:.|.|||:.:.|.||..|:  .:
Zfish   323 FMPCSGLTGANLKESSD---LCPWYTGLPFIPHLDSLPIFSRSSDGPLRLPIVDKYKDMGT--VV 382

  Fly   493 SGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCIISD 557
            .|::|:|.:....::::..:|...:|.||..::........|:.:.:.|..::...:..|.|:.:
Zfish   383 LGKLESGSIAKAQQLIMMPNRHTVEVLSLLSDDVETEYAGPGENLKLRLKGIEEEEILPGFILCN 447

  Fly   558 PQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCL 622
            .:........|.|:|::...|..|..|:..:||..:.||...:..|...:.|.|||..|.:||.:
Zfish   448 AENLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVQISALICLVDKKTGEKSKTRPRFV 512

  Fly   623 GNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            ..:...:..|..:..||:|.:.||.::||..||..|.|||.|.|.|:
Zfish   513 KQDQVCIARLRAAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKL 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	13/61 (21%)
		TEF1	241..669	CDD:227581	166/430 (39%)
		EF1_alpha	249..468	CDD:206670	109/221 (49%)
		HBS1-like_II	474..557	CDD:293912	18/82 (22%)
		HBS1_C_III	561..669	CDD:294008	34/107 (32%)
gspt1	NP_001003992.1	PAM2	<32..44	CDD:284542	2/19 (11%)
		TEF1	138..561	CDD:227581	165/427 (39%)
		EF1_alpha	141..358	CDD:206670	108/219 (49%)
		eRF3_II	366..447	CDD:293906	18/82 (22%)
		eRF3_C_III	453..559	CDD:294003	34/105 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820