Protein Alignment HBS1 and eIF5B

DIOPT Version :10

• Sequence 1: NP_652729.2
• Gene: HBS1 / 117365
• FlyBaseID: FBgn0042712
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_651974.1
• Gene: eIF5B / 44261
• FlyBaseID: FBgn0026259
• Length: 1144
• Species: Drosophila melanogaster
• Alignment Length: 708
• Identity: 140/708 - (19%)
• Similarity: 243/708 - (34%)
• Gaps: 224/708 - (31%)

  Fly    56 ISKNKD----IQEEEAD----EDEDEDAAFAKARRDSESFQMPQLDEIE-QAKLSSCVDEVRSVV 111
            :.|.|:    ::.|||:    |||.|:|.....|.::|..:..:..|.| :|:|.
  Fly   311 LRKRKEEEERLEREEAERIRLEDEREEARLEAVRLEAERKEKKKQREAERKARLK---------- 365

  Fly   112 GDAVSERRIVETSMKFD-YDMQKILD-------EILNEETNKSAKPAV----NKMKAP------- 157
                :|.:::....|.| ...|.:|:       ||.:....:..:|..    ||.|.|
  Fly   366 ----AEGKLLTKKQKEDRARAQALLESLKAQGLEIPDPNDKRPTRPGTRIRPNKKKGPKEEAAEE 426

  Fly   158 ----AAPVLPKTVSKTVPTPPPKISLKEPRRGFEI------PSPKVPSSPVVSGRNTPV------ 206
                |........:........|...:..:..::.      |.|:..:|...:...|..
  Fly   427 EAKAAEAEAQSAAAAAAAAAAEKAEEERVKESWDATDSEAEPEPEEETSQATNNGKTEAAEEENE 491

  Fly   207 ---------------DISAGD-DISRSSATVFKVSKEQAVR-NARQLYEKERADQKSHIH----- 249
                           |.|.|| |.||..:.:....:.:.:| .||.|..:..|::|....
  Fly   492 DTDDDEDDDDDEDDSDDSDGDSDDSREVSVLANDPESRRLRAEARILKRQAEAEKKRSTDELRAG 556

  Fly   250 -MIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERARGITM 313
             :.|:||||.||:.::           .::...|.|:|:                    |.|||.
  Fly   557 VVCVLGHVDTGKTKIL-----------DKLRRTHVQDSE--------------------AGGITQ 590

  Fly   314 DVGQSR-----IETKTKIV-------------TLLDAPGHKDFIPNMISGATQADVALLVVDATR 360
            .:|.:.     |:.:||.|             .::|.|||:.|......|::..|:|:||||...
  Fly   591 QIGATNVPIEAIKEQTKYVKAAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMH 655

  Fly   361 GEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTV-GWSQDRFTEIVTKLKS---------- 414
            |       |..||.|...|::......: |.:||:|.: .|.|....::...||.
  Fly   656 G-------LEPQTIESIQLLKKKKCPFI-VALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQ 712

  Fly   415 ------FLKLAG--------FKDSD----VSFTPCSGLTGENLTKKAQEPALTNWYSGRHLL--- 458
                  .|:.|.        ::::|    :|..|.|.::||.:              |..|.
  Fly   713 QRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGM--------------GNLLFMIA 763

  Fly   459 DVIENFKIPERAIDRPLRMSVSDIYKGTGSG-----FCISGRVETG---VLCLNDKVLVGASREQ 515
            |..:|...........|:.:|.::....|.|     ..|:|::..|   |:...|..:|
  Fly   764 DFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIV------ 822

  Fly   516 AQVKSLTMN-------------EFPQTCVFAGDQVSVTLPALDINNVTVG--CIISDPQTPIPVT 565
            .|::||.|.             |:.:.....|    |.:.|.|:.....|  .:|:.....:.:.
  Fly   823 TQIRSLLMPQPMKELRVKNAYVEYKEVKAAQG----VKIAAKDLEKAIAGINLLIAHKPDEVEIC 883

  Fly   566 TRFQARII---VFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKST---GEVVKK 617
            |...||.:   :.::|:..| |..|.......:|..:....|:.|..|.   |.|||:
  Fly   884 TEEVARELKSALSHIKLAQT-GVHVQASTLGSLEALLEFLRTSKIPYSAIRIGPVVKR 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_652729.2	HBS1_N	83..148	CDD:462642	12/73 (16%)
		TEF1	242..669	CDD:444074	95/461 (21%)
eIF5B	NP_651974.1	PRK04004	553..1129	CDD:457675	93/452 (21%)