DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and CG4849

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	144/732 - (19%)
Similarity:	239/732 - (32%)	Gaps:	274/732 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MDYNDEYDGYDDIYGHSVEDEHCISPTDAQQWLYDRARGQQSISAFISKNKDIQEEEADEDEDED 74
            || :|.||.:.:..|..::     |..:.:|.:|    ||..:       :|..|:..||||.|
  Fly     1 MD-SDLYDEFGNYIGPDLD-----SDEEDEQSIY----GQPDV-------QDDPEDAMDEDEVE- 47

  Fly    75 AAFAKARRDSESFQMPQLDEIEQAKLSSCVDEVRSVVGDAVSERRIVETSMK-FDYDMQKILDEI 138
                           ||.||.:         ||.:||  ...::|...:::: :..|::.|:.|
  Fly    48 ---------------PQEDEDK---------EVTAVV--LHEDKRYYPSAVEVYGPDVETIVQE- 85

  Fly   139 LNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPRRGFEIPSPKVPSSPVVSGRN 203
              |:.....||.:.                  |....|..:||.                 ..:.
  Fly    86 --EDAQPLDKPLIE------------------PVKKLKFQIKEQ-----------------DMQE 113

  Fly   204 TPVDISAGDDISRSSATVFKVSKEQAVRNARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLL 268
            |..|:....|:         :.....:||                 :.::||:..||:|.:..|:
  Fly   114 TTYDMEFMADL---------MDTPPLIRN-----------------VALVGHLHHGKTTFVDCLI 152

  Fly   269 YDTGNVSQRVMHKHEQ----ESKKLGKQSFMYAWVLDETGEER-----ARGITM---DVGQSRIE 321
            ..|          |.|    |.::|.....::      |.:||     |..:|:   ||.|
  Fly   153 RQT----------HPQFETMEERQLRYTDTLF------TEQERGCSIKATPVTLVLQDVKQ---- 197

  Fly   322 TKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQTREHAILVRSLGVN 386
             |:.::.:.|.|||.:|.....:....:|..:|.:||..|...:...|    .:||:..|    .
  Fly   198 -KSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERL----LKHAVQER----Q 253

  Fly   387 QLGVVINKLDTVGWS-----QD---RFTEIVTKLKSFLKLAGFKDSDVSFTP-------CSGLTG 436
            .:.|.|||:|.:...     ||   :...||.::...|...|..|.::..:|       .|.|.|
  Fly   254 AITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSLYG 318

  Fly   437 ENLTKKAQEPALTNWYSGRHLLDVIENF---------------KIPERAIDRP-LRMSVSDIYKG 485
            ...|.|:......:.|.|...||..:..               |.|..:..|. :...:..:||.
  Fly   319 FCFTLKSFAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMYKL 383

  Fly   486 TGSGFCISGRVETGVLCLNDKVLVGASREQAQVKS-------LTMNEFPQTC------------- 530
            ...   :.|.|:|.:.....::.|..|:|  ::||       |..|.|...|
  Fly   384 IAQ---VVGDVDTTLSDTLAELNVRVSKE--EMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKS 443

  Fly   531 -----------VFAGDQVSVTLPALDINNVTVGC-------IISDPQTPIPVTTRFQ--ARIIVF 575
                       ::.|.:..      ||....:.|       :.|....|....|.||  |||:
  Fly   444 PLENAKRKVDHIYTGPKEG------DIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIV-- 500

  Fly   576 NVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICI 640
                                        :.::|  .|:.|    |.||.| ..|.:.|.||.:.:
  Fly   501 ----------------------------SGTLH--AGQEV----RVLGEN-YTLQDEEDSRILQV 530

  Fly   641 ERYADFK-----ELGRV 652
            .|...|:     ||.||
  Fly   531 GRLWVFESRYKVELNRV 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	13/62 (21%)
		TEF1	241..669	CDD:227581	102/500 (20%)
		EF1_alpha	249..468	CDD:206670	57/260 (22%)
		HBS1-like_II	474..557	CDD:293912	18/121 (15%)
		HBS1_C_III	561..669	CDD:294008	24/99 (24%)
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	35/187 (19%)
		PTZ00416	115..957	CDD:240409	106/536 (20%)
		Snu114p	132..340	CDD:206730	56/253 (22%)
		Translation_Factor_II_like	477..568	CDD:295476	25/108 (23%)
		snRNP_III	589..660	CDD:293921
		EF2_IV_snRNP	660..837	CDD:238840
		eEF2_C_snRNP	832..911	CDD:239765
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930