DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HBS1 and si:dkey-37o8.1

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001157466.1	Gene:	si:dkey-37o8.1 / 407641	ZFINID:	ZDB-GENE-030131-5667	Length:	458	Species:	Danio rerio

Alignment Length:	447	Identity:	162/447 - (36%)
Similarity:	252/447 - (56%)	Gaps:	26/447 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 ADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEE 306
            |.::.||::::|||||.||||..|||:|..|.:..|.:.|:|:.:.::||.||.||||||:...|
Zfish     2 AKERIHINLVIIGHVDGGKSTTTGHLVYKCGGIDHRTIEKYEKAATQMGKSSFKYAWVLDKLKAE 66

  Fly   307 RARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGG 371
            |.||||:|:...:..|:....|::|||||:|||.|||:|.:|||.|||:|.|.:||||:|....|
Zfish    67 RERGITIDISLLKFNTQKYTFTIIDAPGHRDFIKNMITGTSQADAALLIVSAAKGEFEAGISRNG 131

  Fly   372 QTREHAILVRSLGVNQLGVVINKLDTV--GWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGL 434
            ||||||:|..:|||.||.|.:||:|..  .:||.|:.|:|..:..|:|..||:...|.|.|.||.
Zfish   132 QTREHALLAYTLGVKQLVVCVNKMDLTEPPFSQKRYDEVVRNVSVFVKKIGFEIGAVPFIPISGW 196

  Fly   435 TGENLTKKAQEPALTNWYS------------GRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTG 487
            :|||:...:|:   ..|:.            ||.||:|:::...|.|...:|||:.:.|:||..|
Zfish   197 SGENMIVPSQK---MQWFKGWKLKRKEGHCHGRTLLEVLDSLHPPVRNAGKPLRLPLQDVYKIGG 258

  Fly   488 SGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVG 552
            .|....|::|||||.....:....::..|:|||:.|:.........|..|...:..:.:.|:..|
Zfish   259 VGTVPVGKIETGVLKPGMVLTFSPAKLTAEVKSIEMHHQGLQTALPGHNVGFNIKNVSVKNLRRG 323

  Fly   553 CIISDPQTPIPV-TTRFQARIIVFNVKVPITMGF-PVLLHHQSLIEPAVVCK---LTASIHKSTG 612
            .:..:.|...|. .:.|.|:||:.|....|.:|: |||..|.:    .|.|:   |...:.:.:|
Zfish   324 DVAGNAQQDPPSDVSSFIAQIIMLNHPGKIKVGYSPVLDCHTT----HVSCRFAELREKLDRRSG 384

  Fly   613 EVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            ..::..|:.|.:...|.|:|..::|:|:|.:..:..|||..:|....|:|.|::..:
Zfish   385 RKLESWPQYLRSGDGATVKLVPNKPLCVESFFHYPPLGRFAVRDLKQTVAVGVIKSV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	162/445 (36%)
		EF1_alpha	249..468	CDD:206670	102/232 (44%)
		HBS1-like_II	474..557	CDD:293912	23/82 (28%)
		HBS1_C_III	561..669	CDD:294008	31/112 (28%)
si:dkey-37o8.1	NP_001157466.1	PTZ00141	1..458	CDD:185474	162/447 (36%)
		EF1_alpha	9..239	CDD:206670	102/232 (44%)
		EF1_alpha_II	244..332	CDD:293894	24/87 (28%)
		EF1_alpha_III	337..438	CDD:294004	30/104 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820