DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and waw

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	124/527 - (23%)
Similarity:	193/527 - (36%)	Gaps:	149/527 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 GDDISRSSATVFKVSKEQAVRNAR-------QLYEKERAD-QKSHIHM--------IVIGHVDAG 259
            ||  .|.||.:...||...|||..       :..|..:|| .:...||        .:|.|||.|
  Fly    49 GD--KRHSAWLVARSKSLLVRNLSTTNQVKGETEEPSQADLLREFAHMPVERIRNFSIIAHVDHG 111

  Fly   260 KSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERARGITMDVGQSRIETKT 324
            ||||...||..||.:: |...:|:               |||....||.||||:....:.|..:.
  Fly   112 KSTLADRLLELTGAIA-RNGGQHQ---------------VLDNLQVERERGITVKAQTASIFHRH 160

  Fly   325 K----IVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQTREHAILVRSLGV 385
            |    ::.|:|.|||.||...:.......|..:|:|||..|       :..||..:..|.:.
  Fly   161 KGQLYLLNLIDTPGHVDFSNEVSRSLAACDGVVLLVDACHG-------VQAQTVANYHLAKQ--- 215

  Fly   386 NQLGV--VINKLDTVGWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGLTGENLTKKAQEPAL 448
            .||.|  |:||:|....:.|   ::...||   .|.|....:|  ...|...|..:::..:.
  Fly   216 RQLAVVPVLNKIDIKHANPD---QVCQDLK---LLFGIDPDEV--LRVSAKLGTGVSEVLER--- 269

  Fly   449 TNWYSGRHLLDVIENFKIPERAIDRPLRMSVSDI----YKGT-GSGFCISGRVETGVLCLNDKVL 508
                       |||....|:...|...|..:.|.    |:|. ...:.::|::|.     |..:.
  Fly   270 -----------VIETVPPPQVQRDSDFRALIFDSWFDKYRGALNLIYVLNGKLEQ-----NQDIQ 318

  Fly   509 VGASREQAQVKSLTM---NEFPQTCVFAGDQVSVTLPALDINNVTVGCIISD------------- 557
            ..|:::...|||:::   .|.|...|.||   .|.|.|.::.| :...|:.|
  Fly   319 SLATKKVYSVKSISVLRPAECPVPDVSAG---QVGLIACNMRN-SKESIVGDTIHLKNQAVAAAG 379

  Fly   558 ---PQTPI------------PVTTRFQARIIVFN-----VKVPIT--------MGFPVLLHHQSL 594
               ||.|:            .|..|.....:|.|     ||:..:        :||..|||.:
  Fly   380 SYRPQQPLVFAGVFPADQSKHVALRSAIDKMVLNDSAVTVKIDSSPALGQGWRLGFLGLLHME-- 442

  Fly   595 IEPAVVCKLTASIHKS---------TGEVVKKKPRCLGNNSCALVELETS----RPICIERYADF 646
                |.|:.....|.:         |..:|...|:.:.......:::..:    .|..|:.|.:.
  Fly   443 ----VFCQRLEQEHGAEPIITAPSVTYRLVLSNPKMIKQQGRDTMDISNAALFPEPHSIKEYYEP 503

  Fly   647 KELGRVM 653
            ..||.::
  Fly   504 LVLGTII 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	113/490 (23%)
		EF1_alpha	249..468	CDD:206670	62/232 (27%)
		HBS1-like_II	474..557	CDD:293912	21/90 (23%)
		HBS1_C_III	561..669	CDD:294008	23/131 (18%)
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	110/480 (23%)
		LepA	100..277	CDD:206677	60/224 (27%)
		EF4_II	285..370	CDD:293900	22/93 (24%)
		EF4_III	386..461	CDD:293917	15/80 (19%)
		lepA_C	502..581	CDD:239680	2/9 (22%)
		LepA_C	589..695	CDD:283959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840