DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HBS1 and eef1a1a

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_956303.1	Gene:	eef1a1a / 336334	ZFINID:	ZDB-GENE-030131-8278	Length:	462	Species:	Danio rerio

Alignment Length:	442	Identity:	162/442 - (36%)
Similarity:	255/442 - (57%)	Gaps:	26/442 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 QKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERA 308
            :|.||:::||||||:||||..|||:|..|.:.:|.:.|.|:|:.::||.||.||||||:...||.
Zfish     4 EKLHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68

  Fly   309 RGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQT 373
            ||||:|:...:.||....||::|||||:|||.|||:|.:|||.|:|:|.|..||||:|....|||
Zfish    69 RGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQT 133

  Fly   374 REHAILVRSLGVNQLGVVINKLDTV--GWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGLTG 436
            ||||:|..:|||.||.|.:||:|:.  .:||.|:.|||.::.:::|..|:....|:|.|.||..|
Zfish   134 REHALLAYTLGVKQLIVGVNKMDSTEPSYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNG 198

  Fly   437 ENLTKKAQEPALTNWY------------SGRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTGSG 489
            :|:.:.:..   .:|:            :|..||:.::..:.|.|..|:|||:.:.|:||..|.|
Zfish   199 DNMLEASPN---MSWFKGWKITRKEGNAAGTTLLEALDAIQPPTRPTDKPLRLPLQDVYKIGGIG 260

  Fly   490 FCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCI 554
            ....||||||:|.....|.........:|||:.|:....:....||.|...:..:.:.::..|.:
Zfish   261 TVPVGRVETGLLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNV 325

  Fly   555 ISDPQT-PIPVTTRFQARIIVFNVKVPITMGF-PVLLHHQSLIEPAVVCK---LTASIHKSTGEV 614
            ..|.:. |......|.|::|:.|....|:.|: |||..|.:    .:.||   |...|.:.:|:.
Zfish   326 AGDSKNDPPQEAANFTAQVIILNHPGQISAGYAPVLDCHTA----HIACKFAELKEKIDRRSGKK 386

  Fly   615 VKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMV 666
            ::..|:.|.:...|:||:...:|:|:|.::::..|||..:|....|:|.|::
Zfish   387 LEDNPKSLKSGDAAIVEMIPGKPMCVESFSEYPPLGRFAVRDMRQTVAVGVI 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	162/442 (37%)
		EF1_alpha	249..468	CDD:206670	100/232 (43%)
		HBS1-like_II	474..557	CDD:293912	24/82 (29%)
		HBS1_C_III	561..669	CDD:294008	31/110 (28%)
eef1a1a	NP_956303.1	PTZ00141	1..460	CDD:185474	162/442 (37%)
		EF1_alpha	9..238	CDD:206670	100/231 (43%)
		EF1_alpha_II	242..332	CDD:293894	26/89 (29%)
		EF1_alpha_III	336..438	CDD:294004	30/105 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820