Protein Alignment HBS1 and hbs1l

DIOPT Version :10

• Sequence 1: NP_652729.2
• Gene: HBS1 / 117365
• FlyBaseID: FBgn0042712
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001295477.1
• Gene: hbs1l / 324267
• ZFINID: ZDB-GENE-030131-2987
• Length: 682
• Species: Danio rerio
• Alignment Length: 716
• Identity: 341/716 - (47%)
• Similarity: 471/716 - (65%)
• Gaps: 81/716 - (11%)

  Fly     1 MSRHRIVRTMDYNDEYDGYDDIYGHSVEDEHCISPTDAQQWLYDRARGQQSISAFISKNKDIQEE 65
            |||||.||..:|:::::. ||:||.||||::||||..|.|::|.|...:|:...     :.::|.
Zfish     1 MSRHRNVRGYNYDEDFED-DDMYGQSVEDDYCISPATAAQFIYSRQDSRQARHV-----ETVEEA 59

  Fly    66 EADEDEDEDAAFAKARRDSESFQMP-------QLDEIEQAKLSSCVDEVRSVVGDAVSERRIVET 123
            |.:|:|:|               ||       .||.::|.:|.||:|::|:|:||::.:..:.:.
Zfish    60 EYEEEEEE---------------MPTSPTMTSTLDSLQQGRLYSCLDQMRTVLGDSIPDSTLTQA 109

  Fly   124 SMKFDYDMQKILDEILNEETNKSA---------KP----AVNKMKAPAAP-------VLPKTVSK 168
            ::|:|.|..:.||.||:|.||..|         :|    |..|.|...||       |:||....
Zfish   110 ALKYDCDPHRALDFILSENTNTQAPSARTNPQLEPNTTAAPQKAKVREAPESRVESEVVPKVARM 174

  Fly   169 TVPTPPPKISLKEPRRGFEI----------------PSPK---VPSSPVVSGRNTPVDISAGDDI 214
            ||       |.|:...||::                |||:   ||::...|.::|..:.||....
Zfish   175 TV-------SGKKQTMGFDVRSAEENGGVAPSLRRGPSPEATAVPTTETPSKQSTVTEDSAAPTP 232

  Fly   215 SRSSATVFKVSKEQAVRNARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVM 279
            :|.|..    ||:|.  |.|...|| |...|..::::||||||||||||||||||..|||::|.|
Zfish   233 TRPSGK----SKQQL--NIRAELEK-RQGGKPLLNLVVIGHVDAGKSTLMGHLLYLLGNVNKRTM 290

  Fly   280 HKHEQESKKLGKQSFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMIS 344
            ||:|||:||.||.||.||||||||||||.||:|||||.::.||.:|:|||:|||||||||||||:
Zfish   291 HKYEQEAKKAGKASFAYAWVLDETGEERDRGVTMDVGMTKFETDSKVVTLMDAPGHKDFIPNMIT 355

  Fly   345 GATQADVALLVVDATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTVGWSQDRFTEIV 409
            ||.|||||:|||||:|||||:|||.||||||||:|||||||.||.|.:||:|.|.|.|:||.||:
Zfish   356 GAAQADVAVLVVDASRGEFEAGFEAGGQTREHALLVRSLGVTQLAVAVNKMDQVNWQQERFQEII 420

  Fly   410 TKLKSFLKLAGFKDSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRP 474
            :||..|||.||||||||.:.|.|||:|||||.|::...||.||:|..|::.|:.||.|:|::::|
Zfish   421 SKLGHFLKQAGFKDSDVFYVPTSGLSGENLTTKSKVADLTAWYTGPCLVEQIDAFKPPQRSVEKP 485

  Fly   475 LRMSVSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSV 539
            .|:.|||::|..|||||::|::|.|.:...||||.....|...||.:::::.......|||.||:
Zfish   486 FRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDKVLAMPPNETCTVKGISLHDEALDWAAAGDHVSL 550

  Fly   540 TLPALDINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLT 604
            |:..:||..:.|||:..||:.||...|||:|||::||:::|||.|||||||:|::.|||.:.||.
Zfish   551 TVTGMDIIKINVGCVFCDPKEPIRACTRFRARILLFNIELPITQGFPVLLHYQTVSEPATIRKLV 615

  Fly   605 ASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            :.:|||:|||:||||:||.....|:||::|.||:.:|.|.|:|||||.|||..|.|||||:||:|
Zfish   616 SVLHKSSGEVLKKKPKCLSKGQNAVVEIQTQRPVAMELYKDYKELGRFMLRYVGSTIAAGVVTEI 680

  Fly   670 R 670
            :
Zfish   681 K 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_652729.2	HBS1_N	83..148	CDD:462642	24/80 (30%)
		TEF1	242..669	CDD:444074	252/426 (59%)
hbs1l	NP_001295477.1	HBS1_N	<78..134	CDD:462642	21/55 (38%)
		PRK12323	<127..>259	CDD:481241	39/145 (27%)
		TEF1	256..682	CDD:444074	253/426 (59%)