DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and eef1a1l1

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_571338.1	Gene:	eef1a1l1 / 30516	ZFINID:	ZDB-GENE-990415-52	Length:	462	Species:	Danio rerio

Alignment Length:	445	Identity:	165/445 - (37%)
Similarity:	255/445 - (57%)	Gaps:	26/445 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 QKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERA 308
            :|:||:::||||||:||||..|||:|..|.:.:|.:.|.|:|:.::||.||.||||||:...||.
Zfish     4 EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68

  Fly   309 RGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQT 373
            ||||:|:...:.||....||::|||||:|||.|||:|.:|||.|:|:|....||||:|....|||
Zfish    69 RGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAGGVGEFEAGISKNGQT 133

  Fly   374 REHAILVRSLGVNQLGVVINKLDTV--GWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGLTG 436
            ||||:|..:|||.||.|.:||:|:.  .:||.||.||..::.:::|..|:..:.|:|.|.||..|
Zfish   134 REHALLAFTLGVKQLIVGVNKMDSTEPPYSQARFEEITKEVSAYIKKIGYNPASVAFVPISGWHG 198

  Fly   437 ENLTKKAQEPALTNWY------------SGRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTGSG 489
            :|:.:.:..   ..|:            ||..|||.::....|.|..|:|||:.:.|:||..|.|
Zfish   199 DNMLEASSN---MGWFKGWKIERKEGNASGTTLLDALDAILPPSRPTDKPLRLPLQDVYKIGGIG 260

  Fly   490 FCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCI 554
            ....||||||||.....|....:....:|||:.|:....|....||.|...:..:.:.::..|.:
Zfish   261 TVPVGRVETGVLKPGMVVTFAPANVTTEVKSVEMHHESLTEATPGDNVGFNVKNVSVKDIRRGNV 325

  Fly   555 ISDPQTPIPV-TTRFQARIIVFNVKVPITMGF-PVLLHHQSLIEPAVVCK---LTASIHKSTGEV 614
            ..|.:...|: ...|.|::|:.|....|:.|: |||..|.:    .:.||   |...|.:.:|:.
Zfish   326 AGDSKNDPPMEAANFNAQVIILNHPGQISQGYAPVLDCHTA----HIACKFAELKEKIDRRSGKK 386

  Fly   615 VKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            ::..|:.|.:...|:||:...:|:|:|.::.:..|||..:|....|:|.|::..:
Zfish   387 LEDNPKALKSGDAAIVEMVPGKPMCVESFSTYPPLGRFAVRDMRQTVAVGVIKSV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	165/443 (37%)
		EF1_alpha	249..468	CDD:206670	101/232 (44%)
		HBS1-like_II	474..557	CDD:293912	26/82 (32%)
		HBS1_C_III	561..669	CDD:294008	31/112 (28%)
eef1a1l1	NP_571338.1	PTZ00141	1..460	CDD:185474	165/445 (37%)
		G1. /evidence=ECO:0000250	14..21		5/6 (83%)
		G2. /evidence=ECO:0000250	70..74		3/3 (100%)
		G3. /evidence=ECO:0000250	91..94		2/2 (100%)
		G4. /evidence=ECO:0000250	153..156		2/2 (100%)
		G5. /evidence=ECO:0000250	194..196		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820