Protein Alignment HBS1 and GSPT1

DIOPT Version :9

• Sequence 1: NP_001286906.1
• Gene: HBS1 / 117365
• FlyBaseID: FBgn0042712
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_002085.3
• Gene: GSPT1 / 2935
• HGNCID: 4621
• Length: 637
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 190/582 - (32%)
• Similarity: 305/582 - (52%)
• Gaps: 57/582 - (9%)

  Fly   135 LDEILNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPR--------RGFEIPSP 191
            |....:.:.|.:|||.|..:.  ||..:|..:......|||........        |...:.|.
Human    61 LSAAFSRQLNVNAKPFVPNVH--AAEFVPSFLRGPAAPPPPVGGAANNHGAGSGAGGRAAPVESS 123

  Fly   192 KVPSSPVVSGRNTPVDISAGDDISRSSATVFKVSKEQA-----------------------VRNA 233
            :...| :..|.|:.|.:...:.|..:..|  ::|.|::                       ..:|
Human   124 QEEQS-LCEGSNSAVSMELSEPIVENGET--EMSPEESWEHKEEISEAEPGGGSLGDGRPPEESA 185

  Fly   234 RQLYEKER-------------ADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQE 285
            .::.|:|.             |.:|.|::::.||||||||||:.|.::|.||.|.:|.:.|:|:|
Human   186 HEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYERE 250

  Fly   286 SKKLGKQSFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQAD 350
            :|:..::::..:|.||...|||.:|.|::||::..||:.|..|:|||||||.|:||||.||:|||
Human   251 AKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQAD 315

  Fly   351 VALLVVDATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLD--TVGWSQDRFTEIVTKLK 413
            :|:||:.|.:||||:|||.||||||||:|.::.||..|.|:|||:|  ||.||.:|:.|...||.
Human   316 LAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLV 380

  Fly   414 SFLKLAGFK-DSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRM 477
            .|||..||. ..|:.|.|||||||.||.:::.   ...||.|...:..::|.....|::|.|:|:
Human   381 PFLKKVGFNPKKDIHFMPCSGLTGANLKEQSD---FCPWYIGLPFIPYLDNLPNFNRSVDGPIRL 442

  Fly   478 SVSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLP 542
            .:.|.||..|:  .:.|::|:|.:|...::::..::...:|..:..::.....|..|:.:.:.|.
Human   443 PIVDKYKDMGT--VVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLK 505

  Fly   543 ALDINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASI 607
            .::...:..|.|:.||.........|.|:|::...|..|..|:..:||..:.||...:..|...:
Human   506 GIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLV 570

  Fly   608 HKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            .|.:||..|.:||.:..:...:..|.|:..||:|.:.||.::||..||..|.|||.|.|.|:
Human   571 DKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKL 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	1/9 (11%)
		TEF1	241..669	CDD:227581	164/443 (37%)
		EF1_alpha	249..468	CDD:206670	107/221 (48%)
		HBS1-like_II	474..557	CDD:293912	16/82 (20%)
		HBS1_C_III	561..669	CDD:294008	34/107 (32%)
GSPT1	NP_002085.3	PAM2	64..81	CDD:284542	5/16 (31%)
		TEF1	210..634	CDD:227581	164/428 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820