Protein Alignment HBS1 and GSPT1

DIOPT Version :10

• Sequence 1: NP_652729.2
• Gene: HBS1 / 117365
• FlyBaseID: FBgn0042712
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_002085.3
• Gene: GSPT1 / 2935
• HGNCID: 4621
• Length: 637
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 190/582 - (32%)
• Similarity: 305/582 - (52%)
• Gaps: 57/582 - (9%)

  Fly   135 LDEILNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPR--------RGFEIPSP 191
            |....:.:.|.:|||.|..:.  ||..:|..:......|||........        |...:.|.
Human    61 LSAAFSRQLNVNAKPFVPNVH--AAEFVPSFLRGPAAPPPPVGGAANNHGAGSGAGGRAAPVESS 123

  Fly   192 KVPSSPVVSGRNTPVDISAGDDISRSSATVFKVSKEQA-----------------------VRNA 233
            :...| :..|.|:.|.:...:.|..:..|  ::|.|::                       ..:|
Human   124 QEEQS-LCEGSNSAVSMELSEPIVENGET--EMSPEESWEHKEEISEAEPGGGSLGDGRPPEESA 185

  Fly   234 RQLYEKER-------------ADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQE 285
            .::.|:|.             |.:|.|::::.||||||||||:.|.::|.||.|.:|.:.|:|:|
Human   186 HEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYERE 250

  Fly   286 SKKLGKQSFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQAD 350
            :|:..::::..:|.||...|||.:|.|::||::..||:.|..|:|||||||.|:||||.||:|||
Human   251 AKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQAD 315

  Fly   351 VALLVVDATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLD--TVGWSQDRFTEIVTKLK 413
            :|:||:.|.:||||:|||.||||||||:|.::.||..|.|:|||:|  ||.||.:|:.|...||.
Human   316 LAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLV 380

  Fly   414 SFLKLAGFK-DSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRM 477
            .|||..||. ..|:.|.|||||||.||.:::.   ...||.|...:..::|.....|::|.|:|:
Human   381 PFLKKVGFNPKKDIHFMPCSGLTGANLKEQSD---FCPWYIGLPFIPYLDNLPNFNRSVDGPIRL 442

  Fly   478 SVSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLP 542
            .:.|.||..|:  .:.|::|:|.:|...::::..::...:|..:..::.....|..|:.:.:.|.
Human   443 PIVDKYKDMGT--VVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLK 505

  Fly   543 ALDINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASI 607
            .::...:..|.|:.||.........|.|:|::...|..|..|:..:||..:.||...:..|...:
Human   506 GIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLV 570

  Fly   608 HKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            .|.:||..|.:||.:..:...:..|.|:..||:|.:.||.::||..||..|.|||.|.|.|:
Human   571 DKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKL 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_652729.2	HBS1_N	83..148	CDD:462642	2/12 (17%)
		TEF1	242..669	CDD:444074	164/429 (38%)
GSPT1	NP_002085.3	PAM2	65..81	CDD:429316	5/15 (33%)
		TEF1	207..636	CDD:444074	165/431 (38%)