DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and GSPT2

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_060564.2	Gene:	GSPT2 / 23708	HGNCID:	4622	Length:	628	Species:	Homo sapiens

Alignment Length:	627	Identity:	200/627 - (31%)
Similarity:	323/627 - (51%)	Gaps:	77/627 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 CVDEV------RSVVGDAVSERRIVETSMKFDYDMQKILDEILNEETNKSAKPAVNKMKAPAAPV 161
            |.|:|      .:..||.||. .:.|.       .::.|....:.:.|.:|||.|..:.  ||..
Human    14 CWDQVDMESPGSAPSGDGVSS-AVAEA-------QREPLSSAFSRKLNVNAKPFVPNVH--AAEF 68

  Fly   162 LPKTVSKTVPTPPPKI-----SLKEPRRGFEIP--------SPKVPS--SPVVS--GRNTPVDI- 208
            :|..:..  ||.||.:     |..|...|...|        :|..||  .|:||  |.|:.|.:
Human    69 VPSFLRG--PTQPPTLPAGSGSNDETCTGAGYPQGKRMGRGAPVEPSREEPLVSLEGSNSAVTME 131

  Fly   209 ---------------------------------SAGDDISRSSATVFKVSKEQAVRNARQLYEKE 240
                                             |:||......:....:.:::.:|.::.:....
Human   132 LSEPVVENGEVEMALEESWEHSKEVSEAEPGGGSSGDSGPPEESGQEMMEEKEEIRKSKSVIVPS 196

  Fly   241 RADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGE 305
            .|.:|.|::::.||||||||||:.|.:::.||.|.:|.:.|:|:|:|:..::::..:|.||...|
Human   197 GAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQE 261

  Fly   306 ERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELG 370
            ||.:|.|::||::..||:.|..|:|||||||.|:||||.||:|||:|:||:.|.:||||:|||.|
Human   262 ERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKG 326

  Fly   371 GQTREHAILVRSLGVNQLGVVINKLD--TVGWSQDRFTEIVTKLKSFLKLAGFK-DSDVSFTPCS 432
            |||||||:|.::.||..|.|:|||:|  ||.||.:|:.|...||..|||..||. ..|:.|.|||
Human   327 GQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKKVGFSPKKDIHFMPCS 391

  Fly   433 GLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTGSGFCISGRVE 497
            ||||.|:.:::.   ...||:|...:..::|.....|:||.|:|:.:.|.||..|:  .:.|::|
Human   392 GLTGANIKEQSD---FCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKYKDMGT--VVLGKLE 451

  Fly   498 TGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCIISDPQTPI 562
            :|.:....::::..::...:|..:..::.....|..|:.:.:.|..::...:..|.|:.||....
Human   452 SGSIFKGQQLVMMPNKHNVEVLGILSDDTETDFVAPGENLKIRLKGIEEEEILPGFILCDPSNLC 516

  Fly   563 PVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSC 627
            .....|..:|::...|..|..|:..:||..:.||...:..|.:.:.|.:||..|.:||.:..:..
Human   517 HSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQV 581

  Fly   628 ALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            .:..|.|:..||:|.:.||.::||..||..|.|||.|.|.|:
Human   582 CIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	9/47 (19%)
		TEF1	241..669	CDD:227581	161/430 (37%)
		EF1_alpha	249..468	CDD:206670	105/221 (48%)
		HBS1-like_II	474..557	CDD:293912	15/82 (18%)
		HBS1_C_III	561..669	CDD:294008	33/107 (31%)
GSPT2	NP_060564.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		9/42 (21%)
		PAM2	47..64	CDD:284542	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..124		14/53 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..195		4/48 (8%)
		TEF1	201..625	CDD:227581	161/428 (38%)
		EF1_alpha	205..421	CDD:206670	105/218 (48%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	210..217		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	266..270		2/3 (67%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	287..290		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	349..352		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	391..393		1/1 (100%)
		eRF3_II	430..511	CDD:293906	15/82 (18%)
		eRF3_C_III	517..623	CDD:294003	33/105 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820