DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HBS1 and Gspt2

DIOPT Version :9

Sequence 1:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_032205.2	Gene:	Gspt2 / 14853	MGIID:	1316727	Length:	632	Species:	Mus musculus

Alignment Length:	625	Identity:	198/625 - (31%)
Similarity:	319/625 - (51%)	Gaps:	68/625 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 CVDEV------RSVVGDAVSERRIVETSMKFDYDMQKILDEILNEETNKSAKPAVNKMKAPAAPV 161
            |.|:|      .:..||.::...:...........:|.|....:.:.|..|||.|..:.  ||..
Mouse    13 CWDQVDMEAPGSAPSGDGIAPAAMAAAEAAEAEAQRKHLSLAFSSQLNIHAKPFVPSVS--AAEF 75

  Fly   162 LPKTVSKTVPTPPPKIS---------LKEPR-RGFEIPSPKVPS--SPVVSGRNT---------- 204
            :|..:..:...|.|..|         ..||. :..|..:|..||  .|:||...:
Mouse    76 VPSFLPGSAQPPAPTASSCDETCIGGAGEPEGKRMEWGAPVEPSKDGPLVSWEGSSSVVTMELSE 140

  Fly   205 PV------------------------DISAGDDISRSSATVFKVSKEQAVRNARQLYEKERADQK 245
            ||                        :.|.||......:....:.:::.||.::.:.....|.:|
Mouse   141 PVVENGEVEMALEESWELKEVSEAKPEASLGDAGPPEESVKEVMEEKEEVRKSKSVSIPSGAPKK 205

  Fly   246 SHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERARG 310
            .|::::.||||||||||:.|.:::.||.|.:|.:.|:|:|:|:..::::..:|.||...|||.:|
Mouse   206 EHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKG 270

  Fly   311 ITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQTRE 375
            .|::||::..||:.|..|:|||||||.|:||||.||:|||:|:||:.|.:||||:|||.||||||
Mouse   271 KTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTRE 335

  Fly   376 HAILVRSLGVNQLGVVINKLD--TVGWSQDRFTEIVTKLKSFLKLAGFK-DSDVSFTPCSGLTGE 437
            ||:|.::.||..|.|:|||:|  ||.||.:|:.|...||..|||..||. ..|:.|.|||||||.
Mouse   336 HAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGA 400

  Fly   438 NLTKKAQEPALTNWYSGRHL---LDVIENFKIPERAIDRPLRMSVSDIYKGTGSGFCISGRVETG 499
            |:.:::.   ...||:|...   ||.:.||   .|:||.|:|:.:.|.||..|:  .:.|::|:|
Mouse   401 NIKEQSD---FCPWYTGLPFIPYLDSLPNF---NRSIDGPIRLPIVDKYKDMGT--VVLGKLESG 457

  Fly   500 VLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCIISDPQTPIPV 564
            .:....::::..::...:|..:..::.....|..|:.:.:.|..::...:..|.|:.:|......
Mouse   458 SIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPSNLCHS 522

  Fly   565 TTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCAL 629
            ...|..:|::...|..|..|:..:||..:.||...:..|.:.:.|.:||..|.:||.:..:...:
Mouse   523 GRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCI 587

  Fly   630 VELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKI 669
            ..|.|:..||:|.:.||.::||..||..|.|||.|.|.|:
Mouse   588 ARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	7/47 (15%)
		TEF1	241..669	CDD:227581	163/433 (38%)
		EF1_alpha	249..468	CDD:206670	108/224 (48%)
		HBS1-like_II	474..557	CDD:293912	15/82 (18%)
		HBS1_C_III	561..669	CDD:294008	33/107 (31%)
Gspt2	NP_032205.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		5/17 (29%)
		PAM2	54..71	CDD:284542	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		5/37 (14%)
		TEF1	205..629	CDD:227581	163/431 (38%)
		EF1_alpha	209..425	CDD:206670	106/218 (49%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	214..221		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	270..274		2/3 (67%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	291..294		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	353..356		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	395..397		1/1 (100%)
		eRF3_II	434..514	CDD:293906	15/81 (19%)
		eRF3_C_III	521..627	CDD:294003	33/105 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820