DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-t1 and HXK2

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_011261.1	Gene:	HXK2 / 852639	SGDID:	S000003222	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	469	Identity:	126/469 - (26%)
Similarity:	217/469 - (46%)	Gaps:	43/469 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PEEDFPEVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQ 71
            |:|...::....|:|....:.|:.:......|:..|||:...:...:|   .:|.|.|||:|.|.
Yeast    20 PKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIP---GWVMDFPTGKESGD 81

  Fly    72 FLALEMMPTNCRIMLVKFSSERDIYTSSKCVIMPHTVAAGRG-TEVFTFLATSIANFVKEK--KV 133
            |||:::..||.|::|||...:|...|:.....:|..:...:. .|::.|:|.|:..|:.|:  :.
Yeast    82 FLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQG 146

  Fly   134 DKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIIN 198
            ..:.:|||..|:|...:..::.|||..|||.|........|||.:|:..:.| ..|.::|:.:||
Yeast   147 ISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK-RNIPIEVVALIN 210

  Fly   199 VGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKL---------MIINSDWA 254
            ...|:|:|..:..|:|::|:|.|:..|..|.:.....|..:|    ||         |.||.::.
Yeast   211 DTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQG----KLSDDIPPSAPMAINCEYG 271

  Fly   255 HFGDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDY 319
            .| |...:...|.:||..:|.||..||.:.:||.|....:||::|:.::.:.|.|.||.......
Yeast   272 SF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSK 335

  Fly   320 IGIQWKLDMVSLIEIVSDPPGVYTKAQEVMDKFRIRH-----CKERDLAALKYICDTVTNRAAML 379
            ....:.:|......|..||   :...::..|.|:...     .:||.|  ::.:.:.:..|||.|
Yeast   336 FDKPFVMDTSYPARIEEDP---FENLEDTDDLFQNEFGINTTVQERKL--IRRLSELIGARAARL 395

  Fly   380 VASGVSCLIDRMRLPQISIAVDGGIYRLHPTFSTVLNKYTRLLAD---------PNYNFEFVITQ 435
            ...|::.:..:.......||.||.:|..:|.|.   .|....|.|         .:|..:.|..:
Yeast   396 SVCGIAAICQKRGYKTGHIAADGSVYNRYPGFK---EKAANALKDIYGWTQTSLDDYPIKIVPAE 457

  Fly   436 DSCGVGAAIMAGMA 449
            |..|.|||::|.:|
Yeast   458 DGSGAGAAVIAALA 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	122/458 (27%)
		Hexokinase_1	13..209	CDD:278764	57/198 (29%)
		Hexokinase_2	215..448	CDD:281689	64/255 (25%)
HXK2	NP_011261.1	COG5026	6..478	CDD:227359	126/469 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343771
Domainoid	1	1.000	138	1.000	Domainoid score	I1047
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9160
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	12	11.860