DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and HXK1

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_116711.3	Gene:	HXK1 / 850614	SGDID:	S000001949	Length:	485	Species:	Saccharomyces cerevisiae

Alignment Length:	465	Identity:	128/465 - (27%)
Similarity:	229/465 - (49%)	Gaps:	36/465 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PEEDFPEVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQ 71
            |:|...|::::..:|....:.|.|:......|:..||::...:...:|   .:|.:.|||:|.|.
Yeast    20 PKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGNIPMIP---GWVMEFPTGKESGN 81

  Fly    72 FLALEMMPTNCRIMLVKFSSERDIYTSSKCVIMPHTVAAGR-GTEVFTFLATSIANFVKEKKV-- 133
            :||:::..||.|::|||.|......|:.....:||.:...: ..|:::|:|.|:.:|:.|:::
Yeast    82 YLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLN 146

  Fly   134 DKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIIN 198
            .||.||||..|::...:..::.|||..|||.|......|.|||.||::.::| .|:.::::.:||
Yeast   147 TKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISK-RELPIEIVALIN 210

  Fly   199 VGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKL---------MIINSDWA 254
            ...|:|:|..:..|:|::|:|.|:..|..:.:.|...|..||    ||         |.||.::.
Yeast   211 DTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEG----KLADDIPSNSPMAINCEYG 271

  Fly   255 HFGDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDY 319
            .| |...|...|.:||..:|.:|..||.:.:||.:....:|||:|:::|.|.:.|.:..:.....
Yeast   272 SF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSK 335

  Fly   320 IGIQWKLDMVSLIEIVSDPPGVYTKAQEVMDK-FRIR-HCKERDLAALKYICDTVTNRAAMLVAS 382
            :...:.:|......|..||........::..| |.:: ...||.|  ::.:|:.:..|||.|...
Yeast   336 LKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKL--IRRLCELIGTRAARLAVC 398

  Fly   383 GVSCLIDRMRLPQISIAVDGGIYRLHPTFSTVLNKYTRLL--------ADPNYNFEFVITQDSCG 439
            |::.:..:.......||.||.:|..:|.|.....|..|.:        .||   ...|..:|..|
Yeast   399 GIAAICQKRGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDP---ITIVPAEDGSG 460

  Fly   440 VGAAIMAGMA 449
            .|||::|.::
Yeast   461 AGAAVIAALS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	125/454 (28%)
		Hexokinase_1	13..209	CDD:278764	59/198 (30%)
		Hexokinase_2	215..448	CDD:281689	65/251 (26%)
HXK1	NP_116711.3	COG5026	6..477	CDD:227359	128/465 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343770
Domainoid	1	1.000	138	1.000	Domainoid score	I1047
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I600
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9160
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	13	12.810