DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and HXK3

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_175220.2	Gene:	HXK3 / 841200	AraportID:	AT1G47840	Length:	493	Species:	Arabidopsis thaliana

Alignment Length:	464	Identity:	117/464 - (25%)
Similarity:	205/464 - (44%)	Gaps:	79/464 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEMMPTNCRIMLVKF--S 90
            |..:.||:..::..||:.:  ....:...|::|..||:|.|.|.|.||::..||.|:..|:.  .
plant    58 LRNVANAIADDMRDGLAVE--GGGDLEMILTFVDALPSGNEEGLFYALDLGGTNFRVRSVQLGGK 120

  Fly    91 SERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNL------PLGIAFAFTLK 149
            .||.:.|.|:.:.:...:..|...|:|.|:|:.:||||.::|..:..|      .||..|:|.:|
plant   121 KERVLATESEQISISQKLMIGTSEELFGFIASKLANFVAKEKPGRFLLEEGRKRELGFTFSFPVK 185

  Fly   150 KLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSLLALCWAQPDT 214
            :.::|.|.|..|||.|...|..||:||..|.:|: :...:.:.|..::|.|.|:|....:...|.
plant   186 QTSIDSGTLSKWTKGFKVSGMEGKNVVACLNEAM-EAHGLDMRVSALVNDGVGTLAGARYWDEDV 249

  Fly   215 RIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEYDRQLDTESIN 279
            .:|:|:|:..|:||||:................|||::|..|...    ..:..:|.::|..|:|
plant   250 MVGVILGTGTNACYVEQKHAIPKLRSKSSSGTTIINTEWGGFSKI----LPQTIFDLEMDETSLN 310

  Fly   280 PGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLDMVSLIEIVSDPPGVYTK 344
            ||..:|||....:.:||:||.::|.:.::..:|                           |.:..
plant   311 PGEHLYEKMISGMYLGEIVRRVLLHMCETSDLF---------------------------GHFAP 348

  Fly   345 AQ-EVMDKFRIRH-CKE--------RDLAALKY-----------------ICDTVTNRAAMLVAS 382
            |: ......|..| ||.        ||:.::.|                 :||||..|...|..:
plant   349 AKLSTPLALRTEHLCKMQEDNTDDLRDVGSILYDFLDVEANMNARRRVVEVCDTVVKRGGRLAGA 413

  Fly   383 GVSCLIDRMRL--------PQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVI--TQDS 437
            |:..:::::..        .:..:|:||.:|..:|.:...:......|..........|  |:|.
plant   414 GIVAILEKIEKDTKRMGSGKRTVVAMDGALYEKYPQYRQYMQDALVELLGHKLASHVAIKHTKDV 478

  Fly   438 CGVGAAIMA 446
            .|:|||::|
plant   479 SGLGAALLA 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	116/462 (25%)
		Hexokinase_1	13..209	CDD:278764	58/188 (31%)
		Hexokinase_2	215..448	CDD:281689	58/269 (22%)
HXK3	NP_175220.2	PLN02914	4..493	CDD:178502	117/464 (25%)
		Hexokinase_1	43..244	CDD:278764	58/188 (31%)
		Hexokinase_2	250..488	CDD:281689	58/269 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	128	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.940