DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and HKL3

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_195497.1	Gene:	HKL3 / 829940	AraportID:	AT4G37840	Length:	493	Species:	Arabidopsis thaliana

Alignment Length:	458	Identity:	109/458 - (23%)
Similarity:	196/458 - (42%)	Gaps:	74/458 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IDDLEKIKNAMDREITMGLSRDHHDRSTVPC------HLSYVQDLPTGRERGQFLALEMMPTNCR 83
            :..|..:.:|:..::|..|        |..|      .:|:...||:|.|:|....:.:  ....
plant    53 VSKLWAVADALVADMTASL--------TAECCGSLNMLVSFTGSLPSGDEKGVHYGVNL--RGKE 107

  Fly    84 IMLVKFS---SERDIYTSSKCVI-MPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGIA- 143
            ::|::.:   :|..|....|..| :|..|..|...|:..|::..:..|:...       |.|.|
plant   108 LLLLRGTLGGNEEPISDVQKHEIPIPDDVLNGSFKELCDFISLELVKFLAMN-------PGGEAE 165

  Fly   144 ----FAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMG--------I 196
                ..|||.:....:|  .........:.....|..::|:|.:....| |::..|        :
plant   166 EVKNLGFTLTRSVEQIG--SHSISSIHRKSLANDDDEKVLKDLVNDMNE-SLETHGLKIRMNTAL 227

  Fly   197 INVGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETY-----EGDEYRKLMIINSDWAHF 256
            ::...|.|....:...||...:.:|...|:.|:|:.:....:     |..|    ::::::|
plant   228 VDNTIGELAGGRYYHKDTVAAVSLGMGTNAAYIEQAQEISRWKSAIREPQE----IVVSTEW--- 285

  Fly   257 GDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIG 321
            ||.........|:|..||.||:|||.||:||......:||:||.::|::.:..|:|.:.....:.
plant   286 GDFRSCHLPITEFDASLDAESLNPGHRIFEKMVSGRYLGEIVRRVLLKMSEESALFGDTLPPKLT 350

  Fly   322 IQ---WKLDMVSLIEIVSDP-PGVYTKAQEVMDKFRIRHCKERDLAALKY---ICDTVTNRAAML 379
            |.   |..||.::.:.:|:. ..|..|.:||   |.|   .:..|||.:.   :||.|..|||.|
plant   351 IPYILWSPDMAAMHQDISEERETVNKKLKEV---FGI---MDSTLAAREVVVEVCDVVAERAARL 409

  Fly   380 VASGVSCLIDRM-RL-PQISIA-VDGGIYRLHPTFSTVLNKYT-RLLADPNYNFEFVITQDSCGV 440
            ..:|:..:|.:: || .::||. |:||:|..:..|...|:... .:|.|.  ..:.|:.:.|.|.
plant   410 AGAGIVGMIKKLGRLEKKMSIVIVEGGLYDHYRVFRNYLHSSVWEMLGDE--LSDHVVIEHSHGG 472

  Fly   441 GAA 443
            .||
plant   473 SAA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	109/458 (24%)
		Hexokinase_1	13..209	CDD:278764	38/206 (18%)
		Hexokinase_2	215..448	CDD:281689	69/245 (28%)
HKL3	NP_195497.1	PLN02596	1..490	CDD:178206	109/458 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	128	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.940