DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-t1 and Hex-C

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_524674.1	Gene:	Hex-C / 44008	FlyBaseID:	FBgn0001187	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	149/451 - (33%)
Similarity:	255/451 - (56%)	Gaps:	11/451 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEM 77
            ||.::.:.|..|...::::.:....|:..||.|..|.::.|.|..:||||||||.|.|::|||::
  Fly     5 EVRELMQPFVLSDYQVQEVYSRFCLEVARGLKRSTHPQANVKCFPTYVQDLPTGDEMGKYLALDL 69

  Fly    78 MPTNCRIMLVKFSSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGI 142
            ..||.|::||......|....|:...:|..:..|.|.::|..:|..:|.||::..:....||||.
  Fly    70 GGTNFRVLLVSLKGHHDATVDSQIYAVPKDLMVGPGVDLFDHIAGCLAKFVEKHDMKTAYLPLGF 134

  Fly   143 AFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSLLAL 207
            .|:|...:|.|..||||.|||.|...|..|:||.::|.:|:.:..:..:.|:.|:|...|:|::.
  Fly   135 TFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRMLHEAIQRRGDADIAVVAILNDTTGTLMSC 199

  Fly   208 CWAQPDTRIGLIMGSIANSCYVERVERCETYEGD--EYRKLMIINSDWAHFGDTGQLDFIRNEYD 270
            .....|.|:|:|:|:..|:||||.||..:....|  :.::.:|:|::|..||:.|||||:|.|||
  Fly   200 AHRNADCRVGVIVGTGCNACYVEDVENVDLLRADFKKTKRSVIVNAEWGAFGEGGQLDFVRTEYD 264

  Fly   271 RQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRR--DYIGI------QWKLD 327
            |::|.:|:|...:::||.:..:.:|.|||:::||.::...||.:..|  ::..:      .::..
  Fly   265 REVDEKSLNRSEQLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETR 329

  Fly   328 MVSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMR 392
            .:|.||..|.|....|: :.|.:.|.:......|...|:|||:.|..|||.|||.|||.|::|..
  Fly   330 YISEIEDDSFPEFASTR-KIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGVSGLVNRTS 393

  Fly   393 LPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMAHANK 453
            ..::.:.:||.:||.||.|...:.:..:.|...:..::.::::|..|.|||::|.:|...|
  Fly   394 NRRVIVGMDGSVYRYHPKFDAYMRQTLQKLVKADKEWDIMLSEDGSGRGAALVAAVASKTK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	146/442 (33%)
		Hexokinase_1	13..209	CDD:278764	66/195 (34%)
		Hexokinase_2	215..448	CDD:281689	80/242 (33%)
Hex-C	NP_524674.1	Hexokinase_1	5..200	CDD:278764	66/194 (34%)
		PTZ00107	13..454	CDD:240270	146/441 (33%)
		Hexokinase_2	207..449	CDD:281689	80/242 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448966
Domainoid	1	1.000	128	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG5026
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
	11	10.850