DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and hk2

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_998231.1	Gene:	hk2 / 406339	ZFINID:	ZDB-GENE-040426-2017	Length:	919	Species:	Danio rerio

Alignment Length:	463	Identity:	161/463 - (34%)
Similarity:	253/463 - (54%)	Gaps:	44/463 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KLFNPSIDDLEK-IKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEMMPTNC 82
            :|.|.::.|:.| .:..||:    ||.||.:..:.|....::|:..|.|.|.|.||||::..||.
Zfish    30 RLSNENLMDVSKRFRKEMDK----GLGRDTNPTAAVKMLPTFVRSTPDGTETGDFLALDLGGTNF 90

  Fly    83 RIMLVKFSS--------ERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLP 139
            |::|||.||        |..||..|:      .:..|.|:|:|..:|..:|||:::..:.:..||
Zfish    91 RVLLVKVSSNGMQKVEMENQIYAISE------NIMRGCGSELFDHIAECLANFLEKLGIKEKKLP 149

  Fly   140 LGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSL 204
            ||..|:|..::..||...||||||.|.|.|..|||||.|||.|:.|..:..:|::.:||...|::
Zfish   150 LGFTFSFPCQQTKLDESFLVSWTKGFKASGVEGKDVVSLLRKAIRKRGDFDIDIVAVINDTVGTM 214

  Fly   205 LALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEY 269
            :...:......||||:|:..|:||:|.:...|..:|||.|  |.:|.:|..|||.|.||.:|.|:
Zfish   215 MTCGYDDHHCEIGLIVGTGTNACYMEEMRHLELVDGDEGR--MCVNMEWGAFGDDGALDDLRTEF 277

  Fly   270 DRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIF-AEDRRDYIGI-QWKLDMVSLI 332
            ||::|..|:|||.:::||....:.||||||:|::::.|.|.:| .....|.:.. .::...||.|
Zfish   278 DREIDAGSLNPGKQLFEKMISGMYMGELVRLILVKMAKDGLLFQGHTTPDLLTTGHFQTSFVSAI 342

  Fly   333 EIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLI--------- 388
            |...|..|: ..|::|:....:....| |..|.:.:|..|:.|||.|.|:.::.::
Zfish   343 ENRKDDEGI-VSAEQVLRGLGLDPTPE-DCVATQRVCQIVSTRAAHLCAASLAAVLRQIRDNKAS 405

  Fly   389 DRMRLPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMA---- 449
            ||:|   .||.|||.:|:.||.|:..|||..|.|. |:.:..|:.::|..|.|||::..:|
Zfish   406 DRLR---TSIGVDGSVYKNHPEFARRLNKMVRSLV-PDCDVRFLRSEDGSGKGAAMVTAVAYRLA 466

  Fly   450 --HANKYK 455
              ||.:.:
Zfish   467 KQHAERQR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	158/446 (35%)
		Hexokinase_1	13..209	CDD:278764	71/198 (36%)
		Hexokinase_2	215..448	CDD:281689	87/243 (36%)
hk2	NP_998231.1	PTZ00107	12..462	CDD:240270	158/449 (35%)
		Hexokinase_1	21..219	CDD:278764	71/198 (36%)
		Hexokinase_2	225..461	CDD:281689	87/243 (36%)
		Hexokinase_1	473..669	CDD:278764	0/2 (0%)
		COG5026	474..911	CDD:227359	0/1 (0%)
		Hexokinase_2	675..910	CDD:281689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020