DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hex-t1 and HK3

DIOPT Version :9

Sequence 1:NP_788744.1 Gene:Hex-t1 / 117364 FlyBaseID:FBgn0042711 Length:465 Species:Drosophila melanogaster
Sequence 2:NP_002106.2 Gene:HK3 / 3101 HGNCID:4925 Length:923 Species:Homo sapiens


Alignment Length:441 Identity:140/441 - (31%)
Similarity:240/441 - (54%) Gaps:28/441 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 FNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEMMPTNCRIM 85
            |..:.|.|..::..|.:.:..||..:......:|   ::|:..|.|.|||.||||::..||.|::
Human   490 FRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLP---TFVRATPDGSERGDFLALDLGGTNFRVL 551

  Fly    86 LVKFSSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGIAFAFTLKK 150
            ||:.::  .:..:|:...:|.|||.|.|.::|..:...|.:|.:::.:...:||||..|:|..::
Human   552 LVRVTT--GVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQ 614

  Fly   151 LALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSLLALCWAQPDTR 215
            |.||.|||::|||.|.|....|:|||.|||:|:.:...:.::|:.|:|...|::::..:..|...
Human   615 LGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCE 679

  Fly   216 IGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEYDRQLDTESINP 280
            ||||:|:..|:||:|.:.......||..|  |.||.:|..|||.|.|..:...:|..:|..||||
Human   680 IGLIVGTGTNACYMEELRNVAGVPGDSGR--MCINMEWGAFGDDGSLAMLSTRFDASVDQASINP 742

  Fly   281 GTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDR------RDYIGIQWKLDMVSLIEIVSDPP 339
            |.:.:||....:.:||:||.|:|.|...|.:|...:      ||....::      |.||.||..
Human   743 GKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKF------LSEIESDSL 801

  Fly   340 GVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMRLPQ------ISI 398
            .: .:.:.:::...:....:..|..|: :|..|:.|||.|..:||:.:::::|..:      :|:
Human   802 AL-RQVRAILEDLGLPLTSDDALMVLE-VCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSV 864

  Fly   399 AVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMA 449
            .|||.:|:|||.||:::....|.|| |.....|:.::|..|.|||::..:|
Human   865 GVDGTLYKLHPRFSSLVAATVRELA-PRCVVTFLQSEDGSGKGAALVTAVA 914

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Hex-t1NP_788744.1 COG5026 13..446 CDD:227359 139/436 (32%)
Hexokinase_1 13..209 CDD:278764 61/187 (33%)
Hexokinase_2 215..448 CDD:281689 77/244 (32%)
HK3NP_002106.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Hexokinase_1 33..230 CDD:376323
PLN02914 72..471 CDD:178502
Hexokinase small subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 84..220
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 95..104
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 185..186
Hexokinase large subdomain 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 221..460
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 221..222
Substrate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 304..307
Glucose-6-phosphate 1 binding. /evidence=ECO:0000250|UniProtKB:P19367 426..428
Hexokinase_1 483..673 CDD:376323 61/187 (33%)
Hexokinase small subdomain 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01084 531..661 49/131 (37%)
Glucose-6-phosphate 2 binding. /evidence=ECO:0000250|UniProtKB:P19367 542..546 0/3 (0%)