DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and HK2

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_005264337.1	Gene:	HK2 / 3099	HGNCID:	4923	Length:	938	Species:	Homo sapiens

Alignment Length:	481	Identity:	151/481 - (31%)
Similarity:	263/481 - (54%)	Gaps:	34/481 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNPEEDFPEVYKVCK-LFNPSIDD--LEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTG 66
            |..|.:..:|.||.: |::..:.|  |.:|.....:|:..||....|..:.|....::|:..|.|
Human    10 FFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDG 74

  Fly    67 RERGQFLALEMMPTNCRIMLVKFSS--------ERDIYTSSKCVIMPHTVAAGRGTEVFTFLATS 123
            .|.|:||||::..||.|::.||.:.        |..||.      :|..:..|.||::|..:|..
Human    75 TEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYA------IPEDIMRGSGTQLFDHIAEC 133

  Fly   124 IANFVKEKKVDKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPE 188
            :|||:.:.::....||||..|:|...:..||...||||||.|.:.|..|:|||.|:|.|:.:..:
Human   134 LANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGD 198

  Fly   189 ISVDVMGIINVGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDW 253
            ..:|::.::|...|:::...:...:..||||:|:.:|:||:|.:...:..||||.|  |.||.:|
Human   199 FDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGR--MCINMEW 261

  Fly   254 AHFGDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRD 318
            ..|||.|.|:.||.|:|:::|..|:|||.:::||....:.||||||:|::::.|...:|......
Human   262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSP 326

  Fly   319 YIGIQWKLDMVSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASG 383
            .:....:.:...:.:|..:..|: .||:||:.:..:...:| |..|...||..|:.|:|.|.|:.
Human   327 ELLNTGRFETKDISDIEGEKDGI-RKAREVLMRLGLDPTQE-DCVATHRICQIVSTRSASLCAAT 389

  Fly   384 VSCLIDRM-------RLPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVG 441
            ::.::.|:       || :.:|.|||.:|:.||.|:..|:|..|.|. |..:..|:.::|..|.|
Human   390 LAAVLQRIKENKGEERL-RSTIGVDGSVYKKHPHFAKRLHKTVRRLV-PGCDVRFLRSEDGSGKG 452

  Fly   442 AAIMAGMAH--ANKYKTDAKLFTMDY 465
            ||::..:|:  |::::...|  |:::
Human   453 AAMVTAVAYRLADQHRARQK--TLEH 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	145/450 (32%)
		Hexokinase_1	13..209	CDD:278764	64/206 (31%)
		Hexokinase_2	215..448	CDD:281689	81/239 (34%)
HK2	XP_005264337.1	PTZ00107	12..460	CDD:240270	146/459 (32%)
		Hexokinase_1	21..219	CDD:278764	63/203 (31%)
		Hexokinase_2	225..459	CDD:281689	81/239 (34%)
		PTZ00107	462..929	CDD:240270	3/17 (18%)
		Hexokinase_1	471..688	CDD:278764	2/8 (25%)
		Hexokinase_2	694..928	CDD:281689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920