DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and HK1

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001309294.1	Gene:	HK1 / 3098	HGNCID:	4922	Length:	952	Species:	Homo sapiens

Alignment Length:	458	Identity:	145/458 - (31%)
Similarity:	258/458 - (56%)	Gaps:	15/458 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EDFPEVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFL 73
            |...::.:....|:.:.|.|.::|..|..|:.:||.:..|:.:.|....|:|:..|.|.|.|.||
Human   500 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 564

  Fly    74 ALEMMPTNCRIMLVKFSS--ERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKD 136
            ||::..||.|::|||..|  :|.:...:|...:|..:..|.|.|:|..:.:.|::|:....:...
Human   565 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGP 629

  Fly   137 NLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGA 201
            .:|||..|:|..::.:||.|||::|||.|.|...:|.|||.|||||:.:..|..:||:.::|...
Human   630 RMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTV 694

  Fly   202 GSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIR 266
            |:::...:.:|...:|||:|:.:|:||:|.::..|..|||:.:  |.||.:|..|||.|.||.||
Human   695 GTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQ--MCINMEWGAFGDNGCLDDIR 757

  Fly   267 NEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLDMVSL 331
            ..|||.:|..|:|.|.:.|||....:.:||:||.|::...|.|.:|.....:.:..:...:...|
Human   758 THYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFL 822

  Fly   332 IEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMRLPQ- 395
            .:|.||...: .:.:.::.:..:....: |...:|.:|..|:.|||.|..:|::.::|::|..:
Human   823 SQIESDRLAL-LQVRAILQQLGLNSTCD-DSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRG 885

  Fly   396 -----ISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMAHANKYK 455
                 :::.|||.:|:|||.||.::::..:.|: |..|..|::::|..|.|||::.  |...:.:
Human   886 LDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELS-PKCNVSFLLSEDGSGKGAALIT--AVGVRLR 947

  Fly   456 TDA 458
            |:|
Human   948 TEA 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	141/440 (32%)
		Hexokinase_1	13..209	CDD:278764	65/197 (33%)
		Hexokinase_2	215..448	CDD:281689	75/238 (32%)
HK1	NP_001309294.1	PTZ00107	47..495	CDD:240270
		Hexokinase_1	56..254	CDD:278764
		Hexokinase_2	260..494	CDD:281689
		PTZ00107	497..942	CDD:240270	142/448 (32%)
		Hexokinase_1	504..702	CDD:278764	65/197 (33%)
		Hexokinase_2	708..942	CDD:281689	75/240 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920