DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-t1 and hxk1

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_592948.1	Gene:	hxk1 / 2542634	PomBaseID:	SPAC24H6.04	Length:	484	Species:	Schizosaccharomyces pombe

Alignment Length:	464	Identity:	136/464 - (29%)
Similarity:	227/464 - (48%)	Gaps:	34/464 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KVCKLFNPSIDDLEK--------IKNAMDR---EITMGLSRDHHDRSTVPCHLSYVQDLPTGRER 69
            |:.|.....:|:||:        :....||   |:..||:.:..|...||   :::...|.|.|.
pombe    22 KLNKTLQDHLDELEEQFTIPTELLHRVTDRFVSELYKGLTTNPGDVPMVP---TWIIGTPDGNEH 83

  Fly    70 GQFLALEMMPTNCRIMLVKF--SSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKK 132
            |.:|||::..||.|:..|:.  :.:.|| |.|| ..:|..:..|....:|.::|..|..||:|..
pombe    84 GSYLALDLGGTNLRVCAVEVQGNGKFDI-TQSK-YRLPQELKVGTREALFDYIADCIKKFVEEVH 146

  Fly   133 VDK-DNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGI 196
            ..| .||.:|..|::...:.:::...||:|||.|...|..|:.|..||..||.:....:|.:..|
pombe   147 PGKSQNLEIGFTFSYPCVQRSINDASLVAWTKGFDIDGVEGESVGPLLSAALKRVGCNNVRLNAI 211

  Fly   197 INVGAGSLLALCWAQPDTRIGLIMGSIANSCYVER---VERCETYEGDEYRKLMIINSDWAHFGD 258
            ::...|:|:|..:|.|.|.||:|.|:..|:||:|:   :.:...|:..|... ||||.:|..| |
pombe   212 LSDTTGTLVASNYASPGTEIGVIFGTGCNACYIEKFSEIPKLHKYDFPEDMN-MIINCEWCDF-D 274

  Fly   259 TGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQ 323
            ...:...|.:||..:|.||..||.:.|||......:|:::|.|:|.|.:.||:|  :.:|...|:
pombe   275 NQHVVLPRTKYDVAIDEESPRPGLQTYEKMIAGCYLGDILRRILLDLYEQGALF--NGQDVTKIR 337

  Fly   324 WKLDM----VSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGV 384
            ..|.|    :|.||:  ||.....:.|.:.::.......|.:...::..|:.:..|:|.|.|.||
pombe   338 DPLAMDTSVLSAIEV--DPFENLDETQTLFEETYGLKTTEEERQFIRRACELIGTRSARLSACGV 400

  Fly   385 SCLIDRMRLPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVI--TQDSCGVGAAIMAG 447
            ..|:.:|..|.:.:..||.:|.|:|.|...|.:..:.:.......:.|.  .:|..|||||:::.
pombe   401 CALVRKMNKPSMIVGTDGSVYNLYPRFKDRLAQAFKDILGEEIGSKVVTIPAEDGSGVGAALVSA 465

  Fly   448 MAHANKYKT 456
            :....|..|
pombe   466 LEAKGKALT 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	134/452 (30%)
		Hexokinase_1	13..209	CDD:278764	60/206 (29%)
		Hexokinase_2	215..448	CDD:281689	71/241 (29%)
hxk1	NP_592948.1	COG5026	10..474	CDD:227359	135/462 (29%)
		Hexokinase_1	30..224	CDD:278764	58/198 (29%)
		Hexokinase_2	230..466	CDD:281689	71/241 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	8	7.880