DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and Gck

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001257778.1	Gene:	Gck / 24385	RGDID:	2670	Length:	498	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	126/396 - (31%)
Similarity:	226/396 - (57%)	Gaps:	16/396 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PTGRERGQFLALEMMPTNCRIMLVKF----SSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSI 124
            |.| |.|.||:|::..||.|:||||.    :.:..:.|..:...:|.....|....:|.:::..|
  Rat   100 PRG-EVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 163

  Fly   125 ANFVKEKKVDKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEI 189
            ::|:.:.::....||||..|:|.::...||.|||::|||.|.|.||.|.::|.|||||:.:..:.
  Rat   164 SDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDF 228

  Fly   190 SVDVMGIINVGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWA 254
            .:||:.::|....::::..:......:|:|:|:..|:||:|.::..|..||||.|  |.:|::|.
  Rat   229 EMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR--MCVNTEWG 291

  Fly   255 HFGDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDY 319
            .|||:|:||....||||.:|..|.|||.::|||..|...||||||:::|:|:....:|..:..:.
  Rat   292 AFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQ 356

  Fly   320 IGIQWKLDMVSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGV 384
            :..:...:...:.::.|| .|...:...::....:|. ...|...::..|::|:.|||.:.::|:
  Rat   357 LRTRGAFETRFVSQVESD-SGDRKQIHNILSTLGLRP-SVTDCDIVRRACESVSTRAAHMCSAGL 419

  Fly   385 SCLIDRMR------LPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAA 443
            :.:|:|||      :.:|::.|||.:|:|||:|....:...|.|. ||....|:.:::..|.|||
  Rat   420 AGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLT-PNCEITFIESEEGSGRGAA 483

  Fly   444 IMAGMA 449
            :::.:|
  Rat   484 LVSAVA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	125/391 (32%)
		Hexokinase_1	13..209	CDD:278764	48/148 (32%)
		Hexokinase_2	215..448	CDD:281689	77/238 (32%)
Gck	NP_001257778.1	Hexokinase_1	<100..248	CDD:376323	48/148 (32%)
Gck	NP_001257778.1	Hexokinase_2	254..488	CDD:377112	77/238 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.030