DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and hkdc1

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_002935347.1	Gene:	hkdc1 / 100485269	XenbaseID:	XB-GENE-1002857	Length:	916	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	141/451 - (31%)
Similarity:	247/451 - (54%)	Gaps:	32/451 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEMMPT 80
            |..:.|:.|...|.::|..|.:|:..||.::.|:.:.|....:||:..|.|.|:|.||||::..|
Frog   472 KTLEAFSLSTKQLLEVKKIMRQEMDRGLKKESHEEAPVKMLPTYVRSTPDGTEKGDFLALDLGGT 536

  Fly    81 NCRIMLVKF-SSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGIAF 144
            |.|::||:. :..|.:...:|...:|.....|.|.|:|..:...||:|::...:...:||||..|
Frog   537 NFRVLLVRVRNGRRGVEMHNKIYTIPQDAMVGTGEELFDHIVHCIADFLEYMGMKGVSLPLGFTF 601

  Fly   145 AFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSLLALCW 209
            :|...:.:|:.|||:.|||.|.|.|..|:|||.||::|:.:..|..:||:.::|...|:::...:
Frog   602 SFPCHQNSLNEGILLKWTKGFKATGCEGEDVVNLLKEAIHRHEEFDLDVVAVVNDTVGTMMTCGY 666

  Fly   210 AQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEYDRQLD 274
            ..|:..:|||:|:.:|:||:|.:...|..||:|.|  |.||.:|..|||...|:..|..:||.:|
Frog   667 EDPNCEMGLIVGTGSNACYMEEMRNVELVEGEEGR--MCINMEWGAFGDNDCLEEFRTVFDRAVD 729

  Fly   275 TESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIF---AEDRRDYIGI-------QWKLDMV 329
            ..|:|||.:.|||....:.:||:||.|::...|.|.:|   ..:|....||       |.:.|.:
Frog   730 ELSLNPGKQRYEKMISGMYLGEIVRNILIDFTKRGLLFRGKISERLKTRGIFETKFLSQIESDRL 794

  Fly   330 SLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMR-- 392
            :|:::           :.::....:....: |...:|.:|..|..|||.|..:||:.::|::|
Frog   795 ALLQV-----------RSILQHLGLNSTCD-DSIIVKEVCTVVARRAAQLCGAGVAAVVDKIREN 847

  Fly   393 ----LPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMA 449
                ..::::.|||.:|:|||.||:::::....|: |.....|:.::|..|.|||::..:|
Frog   848 RGLETLKVTVGVDGTLYKLHPHFSSIMHQTVNDLS-PKCQVTFLQSEDGSGKGAALITAVA 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	140/446 (31%)
		Hexokinase_1	13..209	CDD:278764	64/193 (33%)
		Hexokinase_2	215..448	CDD:281689	75/248 (30%)
hkdc1	XP_002935347.1	PTZ00107	12..460	CDD:240270
		Hexokinase_1	471..666	CDD:376323	64/193 (33%)
		Hexokinase_2	672..906	CDD:377112	75/248 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110