DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and Hkdc1

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_038955090.1	Gene:	Hkdc1 / 100364027	RGDID:	2321830	Length:	915	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	142/443 - (32%)
Similarity:	250/443 - (56%)	Gaps:	12/443 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEM 77
            ::.||..||:.:.:.|..:::.|..|:..||.:..|..:||....:||..:|.|.|:|:||||::
  Rat   469 QIDKVLALFHLTREQLLGVRDKMRAELEYGLKKKTHALATVKMLPTYVYGMPDGTEKGKFLALDL 533

  Fly    78 MPTNCRIMLVKFSSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGI 142
            ..||.|::|||. .:|.:...:|...:|..:..|.|.|:|..:...||:|:....:....||||.
  Rat   534 GGTNFRVLLVKI-RKRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGF 597

  Fly   143 AFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSLLAL 207
            .|:|..::..:|.|.||.|||.|.|....|:|||.:||:|:.:..|..:|::.|:|...|:::..
  Rat   598 TFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTC 662

  Fly   208 CWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEYDRQ 272
            .:..|...||||.|:.:|.||:|.:...|..:|||.|  |.:|::|..|||.|.:|.||.:||::
  Rat   663 GYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGDEGR--MCVNTEWGGFGDNGCIDDIRTQYDKE 725

  Fly   273 LDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLDMVSLIEIVSD 337
            :|..|:|.|.:.|||.:..:.:||:||.|::.|.:.|.:|.....:.:..:...:...|.:|.||
  Rat   726 VDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIESD 790

  Fly   338 PPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMRLPQ------I 396
            ...: .:.:.::.:..:....| |...:|.:|..|:.|||.:..:|::.::::.|..|      :
  Rat   791 RLAL-LQVRRILQQLGLDSTCE-DSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKV 853

  Fly   397 SIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMA 449
            ::.|||.:|:|||.||.:|.:..:.|| |..:..|::::|..|.|||::..:|
  Rat   854 TVGVDGTLYKLHPHFSRILQETVKDLA-PQCDVTFMLSEDGSGKGAALITAVA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	141/438 (32%)
		Hexokinase_1	13..209	CDD:278764	65/195 (33%)
		Hexokinase_2	215..448	CDD:281689	75/238 (32%)
Hkdc1	XP_038955090.1	Hexokinase_1	21..219	CDD:395278
		Hexokinase_2	225..459	CDD:397683
		PTZ00107	466..905	CDD:240270	141/441 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020