DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-t1 and hk1

DIOPT Version :9

Sequence 1:	NP_788744.1	Gene:	Hex-t1 / 117364	FlyBaseID:	FBgn0042711	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001096201.1	Gene:	hk1 / 100124752	XenbaseID:	XB-GENE-944850	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	147/456 - (32%)
Similarity:	250/456 - (54%)	Gaps:	13/456 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANTFNPEEDFPEVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTG 66
            |..:...|...::.:..:.|..|.:.|.::|..|..||..||.:..|:.:.|....:||:..|.|
Frog   458 AVAYRLSEQRRQIDETLEEFKLSREQLLEVKRRMRIEIENGLRKKTHESAKVKMLPTYVRSTPDG 522

  Fly    67 RERGQFLALEMMPTNCRIMLVKFSS--ERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVK 129
            .|.|.||||::..||.|::|||..|  .|.:...:|...:|..|..|.|.|:|..:|..|::|:.
Frog   523 TENGDFLALDLGGTNFRVLLVKIRSGKRRTVEMHNKIYAIPIDVMQGTGEELFDHIAHCISDFLD 587

  Fly   130 EKKVDKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVM 194
            ...:....||||..|:|...:.:||.||||:|||.|.|....|:|||.|||:.:.:..|..:||:
Frog   588 YMGIKGARLPLGFTFSFPCMQTSLDAGILVTWTKGFKATDCEGEDVVNLLREGIKRREEFDLDVV 652

  Fly   195 GIINVGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDT 259
            .|:|...|:::...:..|:..||||:|:.:|:||:|..:..|..:||:.|  |.:|.:|..|||.
Frog   653 AIVNDTVGTMMTCAYEDPNCEIGLIVGTGSNACYMEETKNIEMVDGDQGR--MCVNMEWGAFGDN 715

  Fly   260 GQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQW 324
            |.||.||..||:.:|..|:|.|.:.|||....:.:||:||.|::...|.|.:|.....:.:....
Frog   716 GCLDDIRTVYDKAVDDLSLNSGKQRYEKMISGMYLGEIVRNILIDFTKRGFLFRGQISEALKTTS 780

  Fly   325 KLDMVSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLID 389
            ..:...|.:|.||...: .:.:.::.:..:....: |...:|.:|..|:.|||.:..:|::.::|
Frog   781 IFETKFLSQIESDRLAL-LQVRSILQQLGLNSTCD-DSIIVKEVCGAVSRRAAQVCGAGMAAVVD 843

  Fly   390 RMRLPQ------ISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGM 448
            ::|..:      :::.|||.:|:|||.||.::::..:.|| |..|..|::::|..|.|||::..:
Frog   844 KIRENRGLDHLDVTVGVDGTLYKLHPHFSKIMHQTVKDLA-PKCNVSFLLSEDGSGKGAALITAV 907

  Fly   449 A 449
            |
Frog   908 A 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	COG5026	13..446	CDD:227359	144/440 (33%)
		Hexokinase_1	13..209	CDD:278764	69/197 (35%)
		Hexokinase_2	215..448	CDD:281689	74/238 (31%)
hk1	NP_001096201.1	PTZ00107	12..460	CDD:240270	1/1 (100%)
		Hexokinase_1	469..667	CDD:376323	69/197 (35%)
		Hexokinase_2	673..907	CDD:377112	74/238 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110